Virus Expression Database

GSE106475

Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection

Submitted by E JOHN WHERRY (University of Pennsylvania, USA) on Nov 02 2017

Platform: microarray – [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]

Pubmed: 29320737

Summary Acute respiratory tract viral infections (ARTI) cause significant morbidity and mortality. While CD8 T cells are fundamental to the host response, the transcriptional alterations underlying anti-viral mechanisms within these cells, and the links to clinical characteristics, remain unclear. The transcriptional circuitry in CD8 T cells from acutely ill pediatric patients with influenza-like illness was distinct for different viral pathogens.
We used microarray analysis to profile sorted CD8 T cells from PBMCs of various influenza-like illness patients.

47 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM2838534 Sorted CD8+ T cells Healthy control 9m [Sample3] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838535 Sorted CD8+ T cells Healthy control 10m [Sample9] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838536 Sorted CD8+ T cells Healthy control 1y [Sample15] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838537 Sorted CD8+ T cells Healthy control 1y6m [Sample5] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838538 Sorted CD8+ T cells Healthy control 1y7m [Sample4] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838539 Sorted CD8+ T cells Healthy control 2y [Sample11] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838540 Sorted CD8+ T cells Healthy control 2y3m [Sample2] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838541 Sorted CD8+ T cells Healthy control 3y1m [Sample6] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838542 Sorted CD8+ T cells Healthy control 3y11m [Sample1] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838543 Sorted CD8+ T cells Healthy control 4y6m [Sample17] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838544 Sorted CD8+ T cells Healthy control 4y7m [Sample18] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838545 Sorted CD8+ T cells Healthy control 10y1m [Sample8] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838546 Sorted CD8+ T cells Healthy control 10y1m [Sample14] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838547 Sorted CD8+ T cells Healthy control 10y6m [Sample16] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838548 Sorted CD8+ T cells Healthy control 12y6m [Sample10] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838549 Sorted CD8+ T cells Healthy control 12y4m [Sample13] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838550 Sorted CD8+ T cells Healthy control 16y6m [Sample12] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838551 Sorted CD8+ T cells Healthy control 17y9m [Sample7] cytotoxic T-lymphocyte  healthy Uninfected
GSM2838552 Sorted CD8+ T cells RSV 10d [Sample191] cytotoxic T-lymphocyte  persistent RSV Human orthopneumovirus
GSM2838553 Sorted CD8+ T cells RSV 1y [Sample183] cytotoxic T-lymphocyte  persistent RSV Human orthopneumovirus
GSM2838554 Sorted CD8+ T cells RSV 1y [Sample188] cytotoxic T-lymphocyte  persistent RSV Human orthopneumovirus
GSM2838555 Sorted CD8+ T cells RSV 1y [Sample192] cytotoxic T-lymphocyte  persistent RSV Human orthopneumovirus
GSM2838556 Sorted CD8+ T cells Rhino 11m1w [Sample208] cytotoxic T-lymphocyte  persistent Rhino Rhinovirus A
GSM2838557 Sorted CD8+ T cells Rhino 1y [Sample147] cytotoxic T-lymphocyte  persistent Rhino Rhinovirus A
GSM2838558 Sorted CD8+ T cells Rhino 2y [Sample178] cytotoxic T-lymphocyte  persistent Rhino Rhinovirus A
GSM2838559 Sorted CD8+ T cells Rhino 2y [Sample179] cytotoxic T-lymphocyte  persistent Rhino Rhinovirus A
GSM2838560 Sorted CD8+ T cells Flu A 3w [Sample174] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838561 Sorted CD8+ T cells Flu A 2m [Sample162] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838562 Sorted CD8+ T cells Flu A 4m [Sample164] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838563 Sorted CD8+ T cells Flu A 6m [Sample157] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838564 Sorted CD8+ T cells Flu A 7m2w [Sample169] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838565 Sorted CD8+ T cells Flu A 1y [Sample175] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838566 Sorted CD8+ T cells Flu A 1y [Sample165] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus Data failed QC
pm_mean is 46.034357 (low signal, below threshold of 60)
GSM2838567 Sorted CD8+ T cells Flu A 3y [Sample152] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838568 Sorted CD8+ T cells Flu A 4y [Sample163] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838569 Sorted CD8+ T cells Flu A 5y [Sample158] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838570 Sorted CD8+ T cells Flu A 5y [Sample176] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838571 Sorted CD8+ T cells Flu A 6y [Sample159] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus Data failed QC
all_probeset_mad_residual_mean is 0.964166 (poor normalization, above threshold of 0.80)
GSM2838572 Sorted CD8+ T cells Flu A 6y [Sample167] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838573 Sorted CD8+ T cells Flu A 6y [Sample185] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838574 Sorted CD8+ T cells Flu A 10y [Sample154] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838575 Sorted CD8+ T cells Flu A 12y [Sample125] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838576 Sorted CD8+ T cells Flu A 12y [Sample166] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838577 Sorted CD8+ T cells Flu A 13y [Sample160] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838578 Sorted CD8+ T cells Flu A 17y [Sample143] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838579 Sorted CD8+ T cells Flu A 17y [Sample155] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus
GSM2838580 Sorted CD8+ T cells Flu A 17y [Sample193] cytotoxic T-lymphocyte  persistent Flu A Influenza A virus