Virus Expression Database

GSE115449

RNA-seq of HIV bnAb and control individuals PBMC

Submitted by Todd Bradley (Duke University Medical Center, USA) on Jun 07 2018

Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)

Pubmed: 30270043

Summary We sought to determine differences in transcript expression between a cohort of HIV-infected individuals that either developed broadly neutralizing antibodies (bnAb) or did not develop them (control). With the ultimate goal to identify transcripts that are associated with the development of bnAbs that would identify novel pathways that could be targeted in future vaccine strategies to increase the frequency of individuals that develop bnAbs against HIV. Using this approach we identified that Rab11 recycling endosomes, particularly in dysfunctional natural killer cells are associated with the development of HIV-1 bnAbs.

46 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM3178391 BNab_DDT178LQ peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178394 BNab_BDT17BWJ peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178397 BNab_GDT060M2 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178400 BNab_GDT06P5X peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178402 BNab_CDT052MR peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178403 BNab_DDT06FRH peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178405 BNab_EDTO6G1N peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178407 BNab_GDT052NL peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178410 BNab_EDT07ZLT peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178411 BNab_DDT052NJ peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178414 BNab_GDT06147 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178415 BNab_JDT06P5K peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178416 BNab_GDT06P5N peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178417 BNab_KDT0735T peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178420 BNab_JDT0735X peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178421 BNab_HDT06FP9 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178422 BNab_KDT0736S peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178423 BNab_GDT0736P peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178424 BNab_BDT07ZNY peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178426 BNab_EDT07ZSG peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178429 BNab_BDT06152 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178430 BNab_ADT0614R peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178434 BNab_GDT033GG peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178437 BNab_ADT06P73 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178439 BNab_KDT0614Y peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178444 BNab_BDT0615B peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178449 BNab_BDTO6FXR peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178450 BNab_EDT06FYR peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178451 BNab_BDT06FQY peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178454 BNab_HDT06PC2 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178456 BNab_HDT06PCB peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178460 BNab_CDT052KF peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178461 BNab_FDT052K3 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178464 BNab_BDT0613Q peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178465 BNab_DDT052KR peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178466 BNab_ADT06JT1 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178468 BNab_KDT033RB peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178469 BNab_CDT033GS peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178470 BNab_FDT07ZKM peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178471 BNab_DDT072V1 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178472 BNab_EDT052L0 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178473 BNab_JDT052KT peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178474 BNab_DDT052LD peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178477 BNab_HDT00QLN peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178479 BNab_BDT060P4 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1
GSM3178481 BNab_KDT060P8 peripheral blood mononuclear cell  persistent HIV-1 Human immunodeficiency virus 1