Virus Expression Database

GSE119117

Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection

Submitted by Naglaa Shoukry (CRCHUM, Canada) on Aug 28 2018

Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)

Pubmed: 30222771

Summary Most individuals exposed to hepatitis C virus (HCV) become persistently infected while a minority spontaneously eliminate the virus. Although early immune events influence infection outcome, the cellular composition, molecular effectors, and timeframe of the host response active shortly after viral exposure remain incompletely understood. Employing specimens collected from people who inject drugs (PWID) with high risk of HCV exposure, we utilized RNA-Seq to characterize immune function in peripheral blood before, during, and after acute HCV infection resulting in spontaneous resolution. Our results provide a detailed description of innate immune programs active in peripheral blood during acute HCV infection, which include prominent type I interferon and inflammatory signatures. Innate immune gene expression rapidly returns to pre-infection levels upon viral clearance. This innate response coincides with a decrease in B cell transcriptional signatures. These results represent the first longitudinal transcriptomic characterization of human immune function in acute HCV infection and identify several dynamically regulated features of the complex response to natural HCV exposure.

53 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM3358278 R1-1 peripheral blood mononuclear cell  none Uninfected
GSM3358279 R1-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358280 R1-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358281 R1-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358282 R2-1 peripheral blood mononuclear cell  none Uninfected
GSM3358283 R2-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358284 R2-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358285 R3-1 peripheral blood mononuclear cell  none Uninfected
GSM3358286 R3-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358287 R3-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358288 R3-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358289 R4-1 peripheral blood mononuclear cell  none Uninfected
GSM3358290 R4-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358291 R4-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358292 R4-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358293 R5-1 peripheral blood mononuclear cell  none Uninfected
GSM3358294 R5-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358295 R5-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358296 R5-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358297 R6-1 peripheral blood mononuclear cell  none Uninfected
GSM3358298 R6-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358299 R6-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358300 R6-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358301 C1-1 peripheral blood mononuclear cell  none Uninfected
GSM3358302 C1-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358303 C1-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358304 C1-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358305 C2-1 peripheral blood mononuclear cell  none Uninfected
GSM3358306 C2-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358307 C2-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358308 C3-1 peripheral blood mononuclear cell  none Uninfected
GSM3358309 C3-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358310 C3-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358311 C3-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358312 C4-1 peripheral blood mononuclear cell  none Uninfected
GSM3358313 C4-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358314 C4-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358315 C4-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358316 C5-1 peripheral blood mononuclear cell  none Uninfected
GSM3358317 C5-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358318 C5-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358319 C5-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358320 C6-1 peripheral blood mononuclear cell  none Uninfected
GSM3358321 C6-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358322 C6-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358323 C6-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358324 C7-1 peripheral blood mononuclear cell  none Uninfected
GSM3358325 C7-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358326 C7-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C
GSM3358327 C8-1 peripheral blood mononuclear cell  none Uninfected
GSM3358328 C8-2 peripheral blood mononuclear cell  early acute HCV Hepacivirus C
GSM3358329 C8-3 peripheral blood mononuclear cell  late acute HCV Hepacivirus C
GSM3358330 C8-4 peripheral blood mononuclear cell  followup HCV Hepacivirus C