Virus Expression Database

GSE122967

Structure and degradation of circular RNAs regulate PKR activation in innate immunity

Submitted by Li Yang (Chinese Academy of Sciences, China) on Nov 26 2018

Platform: ngs – Illumina NextSeq 500 (Homo sapiens)

Pubmed: 31031002

Summary RNase L–mediated rapid degradation of circRNAs is required for PKR activation in innate immune responses and linked to the autoimmune disease systemic lupus erythematosus.

8 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM3489316 HeLa ctrl poly(A)+ RNA cervical adenocarcinoma cell line  [HeLa ] none Uninfected
GSM3489317 HeLa poly(I:C) poly(A)+ RNA cervical adenocarcinoma cell line  [HeLa ] none Uninfected Extra interventions
poly(I:C) treated
GSM3489322 HeLa RNaseL KO ctrl poly(A)+ RNA cervical adenocarcinoma cell line  [HeLa ] none Uninfected Extra interventions
RNaseL KO
GSM3489323 HeLa RNaseL KO poly(I:C) poly(A)+ RNA cervical adenocarcinoma cell line  [HeLa ] none Uninfected Extra interventions
RNaseL KO, poly(I:C) treated
GSM3489328 HeLa wt ctrl poly(A)+ RNA replicate 1 cervical adenocarcinoma cell line  [HeLa ] none Uninfected
GSM3489329 HeLa wt ctrl poly(A)+ RNA replicate 2 cervical adenocarcinoma cell line  [HeLa ] none Uninfected
GSM3489330 HeLa wt EMCV poly(A)+ RNA replicate 1 cervical adenocarcinoma cell line  [HeLa ] 24 hrs EMCV Cardiovirus A
GSM3489331 HeLa wt EMCV poly(A)+ RNA replicate 2 cervical adenocarcinoma cell line  [HeLa ] 24 hrs EMCV Cardiovirus A