Virus Expression Database

GSE129180

ZIKV infection strongly induces antiviral immune responses in human NPCs

Submitted by yanhua du (tongji university, China) on Apr 02 2019

Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)

Pubmed: 30952992

Summary To investigate the cellular pathologies in human NPCs after ZIKV infection, we performed global transcriptome profiling of the FD, FV, and H&S organoids at 3 and 6 dpi. We found 105 upregulated genes in the FD NPCs, 60 genes in the FV NPCs, and 168 genes in the H&S NPCs, with at least 1.5-fold differences found between ZIKV-infected groups and the control groups at 6 dpi. Among them, 28 genes overlapped in all three regional NPCs. These 28 common genes exclusively referred to the pathways associated with immune responses to viral infection, which could be clustered to the ISG family.

23 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM3702004 FD6_1 neural stem cell  none Uninfected
GSM3702005 FD6_2 neural stem cell  none Uninfected
GSM3702006 FDz6_1 neural stem cell  6 days ZIKV Zika virus
GSM3702007 FDz6_2 neural stem cell  6 days ZIKV Zika virus
GSM3702008 H&S6_1 neural stem cell  none Uninfected
GSM3702009 H&S6_2 neural stem cell  none Uninfected
GSM3702010 H&Sz6_1 neural stem cell  6 days ZIKV Zika virus
GSM3702011 H&Sz6_2 neural stem cell  6 days ZIKV Zika virus
GSM3702012 FV6_1 neural stem cell  none Uninfected
GSM3702013 FV6_2 neural stem cell  none Uninfected
GSM3702014 FVz6_1 neural stem cell  6 days ZIKV Zika virus
GSM3702015 FVz6_2 neural stem cell  6 days ZIKV Zika virus
GSM3702016 FD3_1 neural stem cell  none Uninfected
GSM3702017 FD3_2 neural stem cell  none Uninfected
GSM3702018 FDz3_1 neural stem cell  3 days ZIKV Zika virus
GSM3702019 H&S3_1 neural stem cell  none Uninfected
GSM3702020 H&S3_2 neural stem cell  none Uninfected
GSM3702021 H&Sz3_1 neural stem cell  3 days ZIKV Zika virus
GSM3702022 H&Sz3_2 neural stem cell  3 days ZIKV Zika virus
GSM3702023 FV3_1 neural stem cell  none Uninfected
GSM3702024 FV3_2 neural stem cell  none Uninfected
GSM3702025 FVz3_1 neural stem cell  3 days ZIKV Zika virus
GSM3702026 FVz3_2 neural stem cell  3 days ZIKV Zika virus