Virus Expression Database

GSE135833

JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response

Submitted by Walter Atwood (Brown University, USA) on Aug 14 2019

Platform: ngs – Illumina HiSeq 2000 (Homo sapiens)

Pubmed: 27381292, 31615962

Summary JC polyomavirus (JCPyV) established a persistent infection, but BK polyomavirus (BKPyV) killed the cells in 15 days. To identify the cellular factors responsible for controlling JCPyV infection and promoting viral persistence, we profiled the transcriptomes of JCPyV- and BKPyV-infected cells at several time points postinfection. We found that interferon-stimulated genes (ISGs) were only activated in the JCPyV and not in the BKPyV-infected cells.

27 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM4034946 BK infected cells at 3 days post infection replicate 1 [BK3DPI1] renal epithelial cell  3 days BKPyV Human polyomavirus 1
GSM4034947 BK infected cells at 3 days post infection replicate 2 [BK3DPI2] renal epithelial cell  3 days BKPyV Human polyomavirus 1
GSM4034948 BK infected cells at 3 days post infection replicate 3 [BK3DPI3] renal epithelial cell  3 days BKPyV Human polyomavirus 1
GSM4034949 BK infected cells at 6 days post infection replicate 1 [BK6DPI1] renal epithelial cell  6 days BKPyV Human polyomavirus 1
GSM4034950 BK infected cells at 6 days post infection replicate 2 [BK6DPI2] renal epithelial cell  6 days BKPyV Human polyomavirus 1
GSM4034951 BK infected cells at 6 days post infection replicate 3 [BK6DPI3] renal epithelial cell  6 days BKPyV Human polyomavirus 1
GSM4034952 BK infected cells at 9 days post infection replicate 1 [BK9DPI1] renal epithelial cell  9 days BKPyV Human polyomavirus 1
GSM4034953 BK infected cells at 9 days post infection replicate 2 [BK9DPI2] renal epithelial cell  9 days BKPyV Human polyomavirus 1
GSM4034954 BK infected cells at 9 days post infection replicate 3 [BK9DPI3] renal epithelial cell  9 days BKPyV Human polyomavirus 1
GSM4034955 JC infected cells at 3 days post infection replicate 1 [JC3DPI1] renal epithelial cell  3 days JCPyV Human polyomavirus 2
GSM4034956 JC infected cells at 3 days post infection replicate 2 [JC3DPI2] renal epithelial cell  3 days JCPyV Human polyomavirus 2
GSM4034957 JC infected cells at 3 days post infection replicate 3 [JC3DPI3] renal epithelial cell  3 days JCPyV Human polyomavirus 2
GSM4034958 JC infected cells at 6 days post infection replicate 1 [JC6DPI1] renal epithelial cell  6 days JCPyV Human polyomavirus 2
GSM4034959 JC infected cells at 6 days post infection replicate 2 [JC6DPI2] renal epithelial cell  6 days JCPyV Human polyomavirus 2
GSM4034960 JC infected cells at 6 days post infection replicate 3 [JC6DPI3] renal epithelial cell  6 days JCPyV Human polyomavirus 2
GSM4034961 JC infected cells at 9 days post infection replicate 1 [JC9DPI1] renal epithelial cell  9 days JCPyV Human polyomavirus 2
GSM4034962 JC infected cells at 9 days post infection replicate 2 [JC9DPI2] renal epithelial cell  9 days JCPyV Human polyomavirus 2
GSM4034963 JC infected cells at 9 days post infection replicate 3 [JC9DPI3] renal epithelial cell  9 days JCPyV Human polyomavirus 2
GSM4034964 Uninfected control cells at 3 days post infection replicate 1 [UI3DPI1] renal epithelial cell  3 days Uninfected
GSM4034965 Uninfected control cells at 3 days post infection replicate 2 [UI3DPI2] renal epithelial cell  3 days Uninfected
GSM4034966 Uninfected control cells at 3 days post infection replicate 3 [UI3DPI3] renal epithelial cell  3 days Uninfected
GSM4034967 Uninfected control cells at 6 days post infection replicate 1 [UI6DPI1] renal epithelial cell  6 days Uninfected
GSM4034968 Uninfected control cells at 6 days post infection replicate 2 [UI6DPI2] renal epithelial cell  6 days Uninfected
GSM4034969 Uninfected control cells at 6 days post infection replicate 3 [UI6DPI3] renal epithelial cell  6 days Uninfected
GSM4034970 Uninfected control cells at 9 days post infection replicate 1 [UI9DPI1] renal epithelial cell  9 days Uninfected
GSM4034971 Uninfected control cells at 9 days post infection replicate 2 [UI9DPI2] renal epithelial cell  9 days Uninfected
GSM4034972 Uninfected control cells at 9 days post infection replicate 3 [UI9DPI3] renal epithelial cell  9 days Uninfected