Virus Expression Database
Submitted by Junko H Ohyashiki (Tokyo Medical University, Japan) on Dec 10 2008
Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Pubmed: 20132662
Summary The contribution of chronic antigen stimulation to the occurrence of lymphoproliferative disorder (LPD) with the gamma-delta T-cell lineage is unclear, despite the fact that Epstein-Barr virus (EBV) positive T-cell LPD is derived from antigen-stimulated cytotoxic T-cells. Given the possible association of antigen stimulation with the development of cytotoxic T-cell LPD, we compared gene expression patterns in Epstein-Barr virus (EBV)-positive gamma-delta T-cell lines derived from patients with nasal T-cell lymphoma and chronic active EBV infection and those in gamma-delta T-cells from healthy volunteers. Three EBV-positive gamma-delta T-cells lines, SNT cells (SNT-8, SNT-13 and SNT-15), were used in this study. SNT-8 was established from patients with nasal T-cell lymphoma and SNT-13, -15 were established from patients with chronic active EBV infection (Zhang Y, et al., Br J Cancer 94:599-608, 2006). All the SNT cells exhibits common rearrangement of Vgamma9-JgammaP and Jdelta3 genes. The gamma-delta T-cells obtained from healthy volunteers were expanded ex vivo by 1 microM of zoledronate (ZOL) plus IL-2 for 14 days incubation.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM349848 | normal gamma-delta T cell duplicate 1 | gamma delta T-lymphocyte  |
normal | Uninfected | ||
| GSM349849 | normal gamma-delta T cell duplicate 2 | gamma delta T-lymphocyte |
normal | Uninfected | ||
| GSM349850 | SNT-8 duplicate 1 | gamma delta T-lymphocyte |
normal | Uninfected | ||
| GSM349851 | SNT-8 duplicate 2 | gamma delta T-lymphocyte |
normal | Uninfected | ||
| GSM349852 | SNT-13 duplicate 1 | gamma delta T-lymphocyte |
EBV | Human gammaherpesvirus 4 | ||
| GSM349853 | SNT-13 duplicate 2 | gamma delta T-lymphocyte |
EBV | Human gammaherpesvirus 4 | ||
| GSM349854 | SNT-15 duplicate 1 | gamma delta T-lymphocyte |
EBV | Human gammaherpesvirus 4 | ||
| GSM349855 | SNT-15 duplicate 2 | gamma delta T-lymphocyte |
EBV | Human gammaherpesvirus 4 |