Virus Expression Database

GSE14816

Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E

Submitted by Michael Bonin (University Tuebingen, Germany) on Feb 13 2009

Platform: microarray – [HG-U133A] Affymetrix Human Genome U133A Array

Pubmed: 19951172

Summary Microarray analysis and quantitative real-time PCR revealed that TB40E infection of DCs led to changes of the gene expression pattern. A variety of pro-inflammatory cytokines and chemokines (CXCL10, CXCL11, CCL5), TLR3 and genes whose products function downstream of the TLR3 signalling pathway (e.g. IFN-α, IFN-β) were significantly upregulated.

6 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM371008 Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E mock sample 1 Immature dendritic cells 24 hrs mock Uninfected
GSM371009 Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E mock sample 2 Immature dendritic cells 24 hrs mock Uninfected
GSM371010 Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E mock sample 3 Immature dendritic cells 24 hrs mock Uninfected
GSM371011 Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E TB treated sample 1 Immature dendritic cells 24 hrs HCMV Strain TB40E Human betaherpesvirus 5
GSM371012 Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E TB treated sample 2 Immature dendritic cells 24 hrs HCMV Strain TB40E Human betaherpesvirus 5
GSM371013 Immune Response of Immature Dendritic Cells after Infection with Human Cytomegalovirus Strain TB40E TB treated sample 3 Immature dendritic cells 24 hrs HCMV Strain TB40E Human betaherpesvirus 5