GSE148696

Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids

Submitted by David Redmond (Weill Cornell Medicine, USA) on Apr 15 2020

Platform: ngs – Illumina NovaSeq 6000 (Homo sapiens)

Pubmed: None listed

Summary We systematically probed which cell types in the colon are permissive to SARS-CoV-2 infection. Transcriptomic analysis following SARS-CoV-2 infection of hPSC-derived colon organoids revealed upregulation of chemokines but not type I/III interferon signaling. A large small molecule screen was also performed.

4 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM4476794	Mock infected colon cells, 1	colon		Mock	Uninfected
GSM4476795	Mock infected colon cells, 2	colon		Mock	Uninfected
GSM4476796	Infected cells for the study of SAR-CoV-2, 1	colon	24 hrs	sars-Cov2	Severe acute respiratory syndrome-related coronavirus
GSM4476797	Infected cells for the study of SAR-CoV-2, 2	colon	24 hrs	sars-Cov2	Severe acute respiratory syndrome-related coronavirus