Virus Expression Database

GSE148696

Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids

Submitted by David Redmond (Weill Cornell Medicine, USA) on Apr 15 2020

Platform: ngs – Illumina NovaSeq 6000 (Homo sapiens)

Pubmed: None listed

Summary We systematically probed which cell types in the colon are permissive to SARS-CoV-2 infection. Transcriptomic analysis following SARS-CoV-2 infection of hPSC-derived colon organoids revealed upregulation of chemokines but not type I/III interferon signaling. A large small molecule screen was also performed.

4 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM4476794 Mock infected colon cells, 1 colon  Mock Uninfected
GSM4476795 Mock infected colon cells, 2 colon  Mock Uninfected
GSM4476796 Infected cells for the study of SAR-CoV-2, 1 colon  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4476797 Infected cells for the study of SAR-CoV-2, 2 colon  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus