Virus Expression Database

GSE151803

Identification of Lead Drug Candidates for COVID-19 based on Drug Screening Using Human Pluripotent Stem Cell-Derived Cells/Organoids

Submitted by David Redmond (Weill Cornell Medicine, USA) on Jun 04 2020

Platform: ngs – Illumina NovaSeq 6000 (Homo sapiens)

Pubmed: None listed

Summary We systematically probed which cell types are permissive to SARS-CoV-2 infection. Transcriptomic analysis following SARS-CoV-2 infection of hPSC-derived pancreatic and lung organoids revealed upregulation of chemokines but not type I/III interferon signaling, similar to what was seen in primary human COVID-19 pulmonary infection.

21 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM4591144 X45.1: Liver Organoid Donor 1 Mock 1 liver  Mock Uninfected
GSM4591145 X45.2: Liver Organoid Donor 1 Mock 2 liver  Mock Uninfected
GSM4591146 X45.3: Liver Organoid Donor 1 SARS-CoV-2 1 liver  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591147 X50.1: Liver Organoid Donor 1 Mock 1 R2 liver  Mock Uninfected
GSM4591148 X50.2: Liver Organoid Donor 1 Mock 2 R2 liver  Mock Uninfected
GSM4591149 X50.3: Liver Organoid Donor 1 SARS-CoV-2 1 R2 liver  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591150 X50.4: Liver Organoid Donor 1 SARS-CoV-2 2 R2 liver  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591151 X50.5: Liver Organoid Donor 2 Mock 1 R2 liver  Mock Uninfected
GSM4591152 X50.6: Liver Organoid Donor 2 Mock 2 R2 liver  Mock Uninfected
GSM4591153 X50.7: Liver Organoid Donor 2 SARS-CoV-2 1 R2 liver  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591154 X50.8: Liver Organoid Donor 2 SARS-CoV-2 2 R2 liver  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591155 X52.22: Liver Organoid Donor 1 SARS-CoV-2 2 liver  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591156 L.2: COVID-19 Lung 51L lung  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591157 L.3: COVID-19 Lung 56L lung  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591158 L.4: COVID-19 Lung 58L lung  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591159 hESC.Pancreas.SARSCoV2.1 pancreatic cell line  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591160 hESC.Pancreas.SARSCoV2.2 pancreatic cell line  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591161 hESC.Pancreas.SARSCoV2.3 pancreatic cell line  24 hrs sars-Cov2 Severe acute respiratory syndrome-related coronavirus
GSM4591162 hESC.Pancreas.mock.1 pancreatic cell line  Mock Uninfected
GSM4591163 hESC.Pancreas.mock.2 pancreatic cell line  Mock Uninfected
GSM4591164 hESC.Pancreas.mock.3 pancreatic cell line  Mock Uninfected