Virus Expression Database
Submitted by Mehul Shamal Suthar (Emory University, USA) on Jul 07 2020
Platform: ngs – Illumina NovaSeq 6000 (Homo sapiens)
Pubmed: 32699094
Summary We performed RNAseq analysis on primary human airway epithelial cultures either mock infected (PBS) or infected with SARS-CoV-2. Transcriptional profiling studies found that infected pHAE cells had a molecular signature dominated by pro-inflammatory cytokines and chemokine induction, including IL-6, TNFα, CXCL8, and identified NF-κB and ATF4 as key drivers of this pro-inflammatory cytokine response. Surprisingly, we observed a lack of a type I or III interferon (IFN) response to SARS-CoV-2 infection
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM4661080 | HAE_Mock_1 | respiratory epithelium cell  |
Mock | Uninfected | ||
| GSM4661081 | HAE_Mock_2 | respiratory epithelium cell |
Mock | Uninfected | ||
| GSM4661082 | HAE_Mock_3 | respiratory epithelium cell |
Mock | Uninfected | ||
| GSM4661083 | HAE_SARSCov2_1 | respiratory epithelium cell |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4661084 | HAE_SARSCoV2_2 | respiratory epithelium cell |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4661085 | HAE_SARSCoV2_3 | respiratory epithelium cell |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus |