Virus Expression Database

GSE15935

Expression data from 'naïve' and HVC-replicon containing Huh7 cells (Clone A cells)

Submitted by Piroska Devay (NIBRI, USA) on May 03 2009

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 19932913

Summary Cyclophilin binding drugs, NIM811 and cyclosporin A (CsA), inhibit the replication of HCV replicon.
We investigated the mode of action of these drugs and identified host factors essential for HCV replication in a subgenomic replicon model.

82 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM399780 Huh7 cells cultured for 12 hours rep1 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected
GSM399781 Huh7 cells cultured for 12 hours rep2 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected
GSM399782 Huh7 cells cultured for 12 hours rep3 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected
GSM399783 Huh7 cells treated with 5uM NIM811 and cultured for 12 hours rep1 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected Extra interventions
NIM811
GSM399784 Huh7 cells treated with 5uM NIM811 and cultured for 12 hours rep2 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected Extra interventions
NIM811
GSM399785 Huh7 cells treated with 5uM NIM811 and cultured for 12 hours rep3 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected Extra interventions
NIM811
GSM399786 Huh7 cells treated with 5uM CsA and cultured for 12 hours rep1 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected Extra interventions
CsA
GSM399787 Huh7 cells treated with 5uM CsA and cultured for 12 hours rep2 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected Extra interventions
CsA
GSM399788 Huh7 cells treated with 5uM CsA and cultured for 12 hours rep3 hepatoma cell line  [Huh-7 ] 12 hrs naïve Uninfected Extra interventions
CsA
GSM399789 Huh7 cells cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected
GSM399790 Huh7 cells cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected
GSM399791 Huh7 cells cultured for 24 hours rep3 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected
GSM399792 Huh7 cells treated with 5uM NIM811 and cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected Extra interventions
NIM811
GSM399793 Huh7 cells treated with 5uM NIM811 and cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected Extra interventions
NIM811
GSM399794 Huh7 cells treated with 5uM NIM811 and cultured for 24 hours rep3 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected Extra interventions
NIM811
GSM399795 Huh7 cells treated with 5uM CsA and cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected Extra interventions
CsA
GSM399796 Huh7 cells treated with 5uM CsA and cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs naïve Uninfected Extra interventions
CsA
GSM399797 Huh7 cells cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected
GSM399798 Huh7 cells cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected
GSM399799 Huh7 cells cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected
GSM399800 Huh7 cells treated with 5uM NIM811 and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399801 Huh7 cells treated with 5uM NIM811 and cultured for48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399802 Huh7 cells treated with 5uM NIM811 and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399803 Huh7 cells treated with 5uM CsA and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399804 Huh7 cells treated with 5uM CsA and cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399805 Huh7 cells treated with 5uM CsA and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399806 Clone A cells cultured for 12 hours rep1 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C
GSM399807 Clone A cells cultured for 12 hours rep2 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C
GSM399808 Clone A cells cultured for 12 hours rep3 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C
GSM399809 Clone A cells treated with 5uM NIM811 and cultured for 12 hours rep1 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399810 Clone A cells treated with 5uM NIM811 and cultured for 12 hours rep2 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399811 Clone A cells treated with 5uM NIM811 and cultured for 12 hours rep3 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399812 Clone A cells treated with 5uM CsA and cultured for 12 hours rep1 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399813 Clone A cells treated with 5uM CsA and cultured for 12 hours rep2 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399814 Clone A cells treated with 5uM CsA and cultured for 12 hours rep3 hepatoma cell line  [Huh-7 ] 12 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399815 Clone A cells cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C
GSM399816 Clone A cells cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C
GSM399817 Clone A cells cultured for 24 hours rep3 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C
GSM399818 Clone A cells treated with 5uM NIM811 and cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399819 Clone A cells treated with 5uM NIM811 and cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399820 Clone A cells treated with 5uM NIM811 and cultured for 24 hours rep3 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399821 Clone A cells treated with 5uM CsA and cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399822 Clone A cells treated with 5uM CsA and cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399823 Clone A cells treated with 5uM CsA and cultured for 24 hours rep3 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399824 Clone A cells cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C
GSM399825 Clone A cells cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C
GSM399826 Clone A cells cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C
GSM399827 Clone A cells treated with 5uM NIM811 and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399828 Clone A cells treated with 5uM NIM811 and cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399829 Clone A cells treated with 5uM NIM811 and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399830 Clone A cells treated with 5uM CsA and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399831 Clone A cells treated with 5uM CsA and cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399832 Clone A cells treated with 5uM CsA and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399833 Huh7 cells cultured for 48 hours rep4 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected
GSM399834 Huh7 cells cultured for 48 hours rep5 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected
GSM399835 Huh7 cells cultured for 48 hours rep6 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected
GSM399836 Clone A cells cultured for 48 hours rep4 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C
GSM399837 Clone A cells cultured for 48 hours rep5 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C
GSM399838 Clone A cells cultured for 48 hours rep6 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C
GSM399839 Huh7 cells treated with 1uM CsA and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399840 Huh7 cells treated with 1uM CsA and cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399841 Huh7 cells treated with 1uM CsA and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399842 Huh7 cells treated with 5uM CsA and cultured for 48 hours rep4 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399843 Huh7 cells treated with 5uM CsA and cultured for 48 hours rep5 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399844 Huh7 cells treated with 5uM CsA and cultured for 48 hours rep6 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
CsA
GSM399845 Huh7 cells treated with 1uM NIM811 and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399846 Huh7 cells treated with 1uM NIM811 and cultured for48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399847 Huh7 cells treated with 1uM NIM811 and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399848 Huh7 cells treated with 5uM NIM811 and cultured for 48 hours rep4 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399849 Huh7 cells treated with 5uM NIM811 and cultured for48 hours rep5 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399850 Huh7 cells treated with 5uM NIM811 and cultured for 48 hours rep6 hepatoma cell line  [Huh-7 ] 48 hrs naïve Uninfected Extra interventions
NIM811
GSM399851 Clone A cells treated with 1uM CsA and cultured for 24 hours rep1 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399852 Clone A cells treated with 1uM CsA and cultured for 24 hours rep2 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399853 Clone A cells treated with 1uM CsA and cultured for 24 hours rep3 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399854 Clone A cells treated with 5uM CsA and cultured for 24 hours rep4 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399855 Clone A cells treated with 5uM CsA and cultured for 24 hours rep5 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399856 Clone A cells treated with 5uM CsA and cultured for 24 hours rep6 hepatoma cell line  [Huh-7 ] 24 hrs HCV replicon Hepacivirus C Extra interventions
CsA
GSM399857 Clone A cells treated with 1uM NIM811 and cultured for 48 hours rep1 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399858 Clone A cells treated with 1uM NIM811 and cultured for 48 hours rep2 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399859 Clone A cells treated with 1uM NIM811 and cultured for 48 hours rep3 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399860 Clone A cells treated with 5uM NIM811 and cultured for 48 hours rep4 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811
GSM399861 Clone A cells treated with 5uM NIM811 and cultured for 48 hours rep5 hepatoma cell line  [Huh-7 ] 48 hrs HCV replicon Hepacivirus C Extra interventions
NIM811