Virus Expression Database
Submitted by sarah natalia mapelli (Humanitas research, Italy) on Oct 28 2020
Platform: ngs – NextSeq 550 (Homo sapiens)
Pubmed: 33208929
Summary PTX3 is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in COVID-194-7. RNA-seq analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in COVID-19 patients. Increased plasma concentrations of PTX3 were detected in 96 COVID-19 patients. PTX3 emerged as a strong independent predictor of 28-day mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized COVID-19 patients. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM4872020 | Healthy Control Lib_CGA-08_S8 | monocyte  |
healthy | Uninfected | ||
| GSM4872021 | Healthy Control Lib_CGA-09_S9 | monocyte |
healthy | Uninfected | ||
| GSM4872022 | Healthy Control Lib_CGA-10_S10 | monocyte |
healthy | Uninfected | ||
| GSM4872023 | COVID-19 Lib_CGA-12_S2 | monocyte |
COVID-19 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4872024 | COVID-19 Lib_CGA-13_S3 | monocyte |
COVID-19 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4872025 | COVID-19 Lib_CGA-14_S4 | monocyte |
COVID-19 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4872026 | COVID-19 Lib_CGA-15_S5 | monocyte |
COVID-19 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4872027 | COVID-19 Lib_CGA-16_S6 | monocyte |
COVID-19 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4872028 | COVID-19 Lib_CGA-17_S7 | monocyte |
COVID-19 | Severe acute respiratory syndrome-related coronavirus |