Virus Expression Database
Submitted by Changfu Yao (cedars-sinai medical center, USA) on Oct 29 2020
Platform: ngs – Illumina NovaSeq 6000 (Homo sapiens)
Pubmed: None listed
Summary Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic resulting from zoonotic transmission of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Severe symptoms include viral pneumonia secondary to infection and inflammation of the lower respiratory tract, in some cases causing death. We developed primary human lung epithelial 5 infection models to understand responses of proximal and distal lung epithelium to SARS-CoV-2 infection. Differentiated air-liquid interface cultures of proximal airway epithelium and 3D organoid cultures of alveolar epithelium were readily infected by SARS-CoV-2 leading to an epithelial cell-autonomous proinflammatory response. We validated the efficacy of selected candidate COVID-19 drugs confirming that Remdesivir strongly suppressed viral 10 infection/replication. We provide a relevant platform for studying COVID-19 pathobiology and for rapid drug screening against SARS-CoV-2 and future emergent respiratory pathogens.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM4873336 | cc01-20covid1 | alveolar cell type II  |
SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4873337 | cc01-20covid2 | alveolar cell type II |
SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4873338 | cc01-20mock1 | alveolar cell type II |
Mock | Uninfected | ||
| GSM4873339 | cc01-20mock2 | alveolar cell type II |
Mock | Uninfected | ||
| GSM4873340 | cc03-19covid | alveolar cell type II |
SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4873341 | cc03-19mock1 | alveolar cell type II |
Mock | Uninfected | ||
| GSM4873342 | cc03-20covid1 | alveolar cell type II |
SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4873343 | cc03-20covid2 | alveolar cell type II |
SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | ||
| GSM4873344 | cc03-20mock1 | alveolar cell type II |
Mock | Uninfected | ||
| GSM4873345 | cc03-20mock2 | alveolar cell type II |
Mock | Uninfected |