Virus Expression Database

GSE16354

Infection of Lymphatic and Blood Vessel Endothelial Cells (LEC and BEC) with KSHV

Submitted by Stephen Henderson (UCL, United Kingdom) on May 31 2009

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 20080955

Summary Kaposi sarcoma is the most common cancer in AIDS patients and is typified by red skin lesions. The disease is caused by the KSHV virus (HHV8) and is recognisable by its distinctive red skin lesions. The lesions are KSHV-infected spindle cells, most commonly the lymphatic endothelial and blood vessel endothelial cells (LEC and BEC), plus surrounding stroma. The effects of KSHV infection of both LEC and BEC were assayed using Affymetrix hgu133plus2 chips at 72 hours post infection.

24 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM410666 LEC control, rep1 lymphatic endothelial cell  control Uninfected
GSM410667 LEC control, rep2 lymphatic endothelial cell  control Uninfected
GSM410668 LEC control, rep3 lymphatic endothelial cell  control Uninfected
GSM410669 LEC control, rep4 lymphatic endothelial cell  control Uninfected
GSM410670 LEC control, rep5 lymphatic endothelial cell  control Uninfected
GSM410671 LEC control, rep6 lymphatic endothelial cell  control Uninfected
GSM410672 LEC KSHV 72h, rep1 lymphatic endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410673 LEC KSHV 72h, rep2 lymphatic endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410674 LEC KSHV 72h, rep3 lymphatic endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410675 LEC KSHV 72h, rep4 lymphatic endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410676 LEC KSHV 72h, rep5 lymphatic endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410677 LEC KSHV 72h, rep6 lymphatic endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410678 BEC control, rep1 vascular endothelial cell  control Uninfected
GSM410679 BEC control, rep2 vascular endothelial cell  control Uninfected
GSM410680 BEC control, rep3 vascular endothelial cell  control Uninfected
GSM410681 BEC control, rep4 vascular endothelial cell  control Uninfected
GSM410682 BEC control, rep5 vascular endothelial cell  control Uninfected
GSM410683 BEC control, rep6 vascular endothelial cell  control Uninfected
GSM410684 BEC KSHV 72h, rep1 vascular endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410685 BEC KSHV 72h, rep2 vascular endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410686 BEC KSHV 72h, rep3 vascular endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410687 BEC KSHV 72h, rep4 vascular endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410688 BEC KSHV 72h, rep5 vascular endothelial cell  72 hrs KSHV Human gammaherpesvirus 8
GSM410689 BEC KSHV 72h, rep6 vascular endothelial cell  72 hrs KSHV Human gammaherpesvirus 8