Virus Expression Database
Submitted by Sebla Bulent Kutluay (Washington University School of Medicine, USA) on Dec 19 2020
Platform: ngs – Illumina NextSeq 500 (Homo sapiens)
Pubmed: None listed
Summary Purpose: The goal of this study is to define the transcriptional response of H522 cells to SARS-CoV-2 infection.
Methods:H522 cells were infected with SARS-CoV-2 at varying multiplicities of infection and samples processed for RNA-seq at 4, 24, 48, 72 and 96 hours post-infection.
Results: We provide the transcriptomic and translatomic landscape of SARS-CoV-2-infected H522 cells from multiple RNA-seq libraries. We found that the robust transcriptional upregulation of numerous type I interferon and cell cycle associated genes in SARS-CoV-2-infected cells.
Conclusions: Our study represents the detailed analysis of transcriptional responses of H522 cells to SARS-CoV-2 and demonstrates upregulation of key pathways that may paly a role in disease pathogenesis.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM4981385 | A6-Rep1-Kutluay_H522-MOI0-015-mock | non-small cell lung cancer cell line  [NCI-H522  ] |
Mock | Uninfected | ||
| GSM4981386 | A3-Rep1-Kutluay_H522-MOI0-015-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981387 | A1-Rep1-Kutluay_H522-MOI0-015-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981388 | A2-Rep1-Kutluay_H522-MOI0-015-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981389 | A4-Rep1-Kutluay_H522-MOI0-015-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981390 | A5-Rep1-Kutluay_H522-MOI0-015-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981391 | A12-Rep1-Kutluay_H522-MOI0-06-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981392 | A9-Rep1-Kutluay_H522-MOI0-06-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981393 | A7-Rep1-Kutluay_H522-MOI0-06-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981394 | A8-Rep1-Kutluay_H522-MOI0-06-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981395 | A10-Rep1-Kutluay_H522-MOI0-06-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981396 | A11-Rep1-Kutluay_H522-MOI0-06-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981397 | A18-Rep1-Kutluay_H522-MOI0-25-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981398 | A15-Rep1-Kutluay_H522-MOI0-25-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981399 | A13-Rep1-Kutluay_H522-MOI0-25-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981400 | A14-Rep1-Kutluay_H522-MOI0-25-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981401 | A16-Rep1-Kutluay_H522-MOI0-25-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981402 | A17-Rep1-Kutluay_H522-MOI0-25-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981403 | A24-Rep1-Kutluay_H522-MOI1-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981404 | A21-Rep1-Kutluay_H522-MOI1-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981405 | A19-Rep1-Kutluay_H522-MOI1-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981406 | A20-Rep1-Kutluay_H522-MOI1-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981407 | A22-Rep1-Kutluay_H522-MOI1-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981408 | A23-Rep1-Kutluay_H522-MOI1-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981409 | B6-Rep2-Kutluay_H522-MOI0-015-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981410 | B3-Rep2-Kutluay_H522-MOI0-015-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981411 | B1-Rep2-Kutluay_H522-MOI0-015-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981412 | B2-Rep2-Kutluay_H522-MOI0-015-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981413 | B4-Rep2-Kutluay_H522-MOI0-015-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981414 | B5-Rep2-Kutluay_H522-MOI0-015-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981415 | B12-Rep2-Kutluay_H522-MOI0-06-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981416 | B9-Rep2-Kutluay_H522-MOI0-06-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981417 | B7-Rep2-Kutluay_H522-MOI0-06-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981418 | B8-Rep2-Kutluay_H522-MOI0-06-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981419 | B10-Rep2-Kutluay_H522-MOI0-06-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981420 | B11-Rep2-Kutluay_H522-MOI0-06-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981421 | B18-Rep2-Kutluay_H522-MOI0-25-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981422 | B15-Rep2-Kutluay_H522-MOI0-25-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981423 | B13-Rep2-Kutluay_H522-MOI0-25-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981424 | B14-Rep2-Kutluay_H522-MOI0-25-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981425 | B16-Rep2-Kutluay_H522-MOI0-25-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981426 | B17-Rep2-Kutluay_H522-MOI0-25-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981427 | B24-Rep2-Kutluay_H522-MOI1-mock | non-small cell lung cancer cell line [NCI-H522 ] |
Mock | Uninfected | ||
| GSM4981428 | B21-Rep2-Kutluay_H522-MOI1-4hpi | non-small cell lung cancer cell line [NCI-H522 ] |
4 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981429 | B19-Rep2-Kutluay_H522-MOI1-24hpi | non-small cell lung cancer cell line [NCI-H522 ] |
24 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981430 | B20-Rep2-Kutluay_H522-MOI1-48hpi | non-small cell lung cancer cell line [NCI-H522 ] |
48 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981431 | B22-Rep2-Kutluay_H522-MOI1-72hpi | non-small cell lung cancer cell line [NCI-H522 ] |
72 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus | |
| GSM4981432 | B23-Rep2-Kutluay_H522-MOI1-96hpi | non-small cell lung cancer cell line [NCI-H522 ] |
96 hrs | SARS-CoV-2 | Severe acute respiratory syndrome-related coronavirus |