Virus Expression Database

GSE17156

Gene expression signatures of symptomatic respiratory viral infection in adults

Submitted by Geoffrey S Ginsburg (Duke Institute for Genome Sciences & Policy, USA) on Jul 16 2009

Platform: microarray – [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

Pubmed: 19664979

Summary Diagnosis of acute respiratory viral infection is currentlybased on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis.
We used microarrays to capture peripheral blood gene expression at baseline and time of peak symptoms in healthy volunteers infected intranasally with influenza A H3N2, respiratory syncytial virus or rhinovirus. We determined groups of coexpressed genes that accurately classified symptomatic versus asymptomatic individuals.

113 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM429202 rhinovirus challenge sample at baseline_Rhino001 peripheral blood  rhinovirus Uninfected
GSM429203 rhinovirus challenge sample at T_Rhino001 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429204 rhinovirus challenge sample at baseline_Rhino002 peripheral blood  rhinovirus Uninfected
GSM429205 rhinovirus challenge sample at T_Rhino002 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429206 rhinovirus challenge sample at baseline_Rhino003 peripheral blood  rhinovirus Uninfected
GSM429207 rhinovirus challenge sample at T_Rhino003 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429208 rhinovirus challenge sample at baseline_Rhino004 peripheral blood  rhinovirus Uninfected
GSM429209 rhinovirus challenge sample at T_Rhino004 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429210 rhinovirus challenge sample at baseline_Rhino005 peripheral blood  rhinovirus Uninfected
GSM429211 rhinovirus challenge sample at T_Rhino005 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429212 rhinovirus challenge sample at baseline_Rhino006 peripheral blood  rhinovirus Uninfected
GSM429213 rhinovirus challenge sample at T_Rhino006 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429214 rhinovirus challenge sample at baseline_Rhino007 peripheral blood  rhinovirus Uninfected
GSM429215 rhinovirus challenge sample at T_Rhino007 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429216 rhinovirus challenge sample at baseline_Rhino008 peripheral blood  rhinovirus Uninfected
GSM429217 rhinovirus challenge sample at T_Rhino008 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429218 rhinovirus challenge sample at baseline_Rhino009 peripheral blood  rhinovirus Uninfected
GSM429219 rhinovirus challenge sample at T_Rhino009 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429220 rhinovirus challenge sample at baseline_Rhino010 peripheral blood  rhinovirus Uninfected
GSM429221 rhinovirus challenge sample at T_Rhino010 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429222 rhinovirus challenge sample at baseline_Rhino011 peripheral blood  rhinovirus Uninfected
GSM429223 rhinovirus challenge sample at T_Rhino011 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429224 rhinovirus challenge sample at baseline_Rhino012 peripheral blood  rhinovirus Uninfected
GSM429225 rhinovirus challenge sample at T_Rhino012 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429226 rhinovirus challenge sample at baseline_Rhino013 peripheral blood  rhinovirus Uninfected
GSM429227 rhinovirus challenge sample at T_Rhino013 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429228 rhinovirus challenge sample at baseline_Rhino014 peripheral blood  rhinovirus Uninfected
GSM429229 rhinovirus challenge sample at T_Rhino014 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429230 rhinovirus challenge sample at baseline_Rhino015 peripheral blood  rhinovirus Uninfected
GSM429231 rhinovirus challenge sample at T_Rhino015 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429232 rhinovirus challenge sample at T_Rhino016 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429233 rhinovirus challenge sample at baseline_Rhino017 peripheral blood  rhinovirus Uninfected
GSM429234 rhinovirus challenge sample at T_Rhino017 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429235 rhinovirus challenge sample at baseline_Rhino018 peripheral blood  rhinovirus Uninfected
GSM429236 rhinovirus challenge sample at T_Rhino018 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429237 rhinovirus challenge sample at baseline_Rhino019 peripheral blood  rhinovirus Uninfected
GSM429238 rhinovirus challenge sample at T_Rhino019 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429239 rhinovirus challenge sample at baseline_Rhino020 peripheral blood  rhinovirus Uninfected
GSM429240 rhinovirus challenge sample at T_Rhino020 peripheral blood  peak symptoms rhinovirus Rhinovirus A
GSM429241 respiratory syncytial virus challenge sample at baseline_RSV001 peripheral blood  RSV Uninfected
GSM429242 respiratory syncytial virus challenge sample at T_RSV001 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429243 respiratory syncytial virus challenge sample at baseline_RSV002 peripheral blood  RSV Uninfected
GSM429244 respiratory syncytial virus challenge sample at T_RSV002 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429245 respiratory syncytial virus challenge sample at baseline_RSV003 peripheral blood  RSV Uninfected
GSM429246 respiratory syncytial virus challenge sample at T_RSV003 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429247 respiratory syncytial virus challenge sample at baseline_RSV004 peripheral blood  RSV Uninfected
GSM429248 respiratory syncytial virus challenge sample at T_RSV004 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429249 respiratory syncytial virus challenge sample at baseline_RSV005 peripheral blood  RSV Uninfected
GSM429250 respiratory syncytial virus challenge sample at T_RSV005 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429251 respiratory syncytial virus challenge sample at baseline_RSV006 peripheral blood  RSV Uninfected
GSM429252 respiratory syncytial virus challenge sample at T_RSV006 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429253 respiratory syncytial virus challenge sample at baseline_RSV007 peripheral blood  RSV Uninfected
GSM429254 respiratory syncytial virus challenge sample at T_RSV007 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429255 respiratory syncytial virus challenge sample at baseline_RSV008 peripheral blood  RSV Uninfected
GSM429256 respiratory syncytial virus challenge sample at T_RSV008 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429257 respiratory syncytial virus challenge sample at baseline_RSV009 peripheral blood  RSV Uninfected
GSM429258 respiratory syncytial virus challenge sample at T_RSV009 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429259 respiratory syncytial virus challenge sample at baseline_RSV010 peripheral blood  RSV Uninfected
GSM429260 respiratory syncytial virus challenge sample at T_RSV010 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429261 respiratory syncytial virus challenge sample at baseline_RSV011 peripheral blood  RSV Uninfected
GSM429262 respiratory syncytial virus challenge sample at T_RSV011 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429263 respiratory syncytial virus challenge sample at baseline_RSV012 peripheral blood  RSV Uninfected
GSM429264 respiratory syncytial virus challenge sample at T_RSV012 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429265 respiratory syncytial virus challenge sample at baseline_RSV013 peripheral blood  RSV Uninfected
GSM429266 respiratory syncytial virus challenge sample at T_RSV013 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429267 respiratory syncytial virus challenge sample at baseline_RSV014 peripheral blood  RSV Uninfected
GSM429268 respiratory syncytial virus challenge sample at T_RSV014 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429269 respiratory syncytial virus challenge sample at baseline_RSV015 peripheral blood  RSV Uninfected
GSM429270 respiratory syncytial virus challenge sample at T_RSV015 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429271 respiratory syncytial virus challenge sample at baseline_RSV016 peripheral blood  RSV Uninfected
GSM429272 respiratory syncytial virus challenge sample at T_RSV016 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429273 respiratory syncytial virus challenge sample at baseline_RSV017 peripheral blood  RSV Uninfected
GSM429274 respiratory syncytial virus challenge sample at T_RSV017 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429275 respiratory syncytial virus challenge sample at baseline_RSV018 peripheral blood  RSV Uninfected
GSM429276 respiratory syncytial virus challenge sample at T_RSV018 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429277 respiratory syncytial virus challenge sample at baseline_RSV019 peripheral blood  RSV Uninfected
GSM429278 respiratory syncytial virus challenge sample at T_RSV019 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429279 respiratory syncytial virus challenge sample at baseline_RSV020 peripheral blood  RSV Uninfected
GSM429280 respiratory syncytial virus challenge sample at T_RSV020 peripheral blood  peak symptoms RSV Human orthopneumovirus
GSM429281 Influenza A H3N2 challenge sample at baseline_Flu001 peripheral blood  Influenza A H3N2 Uninfected
GSM429282 Influenza A H3N2 challenge sample at T_Flu001 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429283 Influenza A H3N2 challenge sample at baseline_Flu002 peripheral blood  Influenza A H3N2 Uninfected
GSM429284 Influenza A H3N2 challenge sample at T_Flu002 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429285 Influenza A H3N2 challenge sample at baseline_Flu003 peripheral blood  Influenza A H3N2 Uninfected
GSM429286 Influenza A H3N2 challenge sample at T_Flu003 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429287 Influenza A H3N2 challenge sample at baseline_Flu004 peripheral blood  Influenza A H3N2 Uninfected
GSM429288 Influenza A H3N2 challenge sample at T_Flu004 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429289 Influenza A H3N2 challenge sample at baseline_Flu005 peripheral blood  Influenza A H3N2 Uninfected
GSM429290 Influenza A H3N2 challenge sample at T_Flu005 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429291 Influenza A H3N2 challenge sample at baseline_Flu006 peripheral blood  Influenza A H3N2 Uninfected
GSM429292 Influenza A H3N2 challenge sample at T_Flu006 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429293 Influenza A H3N2 challenge sample at baseline_Flu007 peripheral blood  Influenza A H3N2 Uninfected
GSM429294 Influenza A H3N2 challenge sample at T_Flu007 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429295 Influenza A H3N2 challenge sample at baseline_Flu008 peripheral blood  Influenza A H3N2 Uninfected
GSM429296 Influenza A H3N2 challenge sample at T_Flu008 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429297 Influenza A H3N2 challenge sample at baseline_Flu009 peripheral blood  Influenza A H3N2 Uninfected
GSM429298 Influenza A H3N2 challenge sample at T_Flu009 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429299 Influenza A H3N2 challenge sample at baseline_Flu010 peripheral blood  Influenza A H3N2 Uninfected
GSM429300 Influenza A H3N2 challenge sample at T_Flu010 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429301 Influenza A H3N2 challenge sample at baseline_Flu011 peripheral blood  Influenza A H3N2 Uninfected
GSM429302 Influenza A H3N2 challenge sample at T_Flu011 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429303 Influenza A H3N2 challenge sample at baseline_Flu012 peripheral blood  Influenza A H3N2 Uninfected
GSM429304 Influenza A H3N2 challenge sample at T_Flu012 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429305 Influenza A H3N2 challenge sample at baseline_Flu013 peripheral blood  Influenza A H3N2 Uninfected
GSM429306 Influenza A H3N2 challenge sample at T_Flu013 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429307 Influenza A H3N2 challenge sample at baseline_Flu014 peripheral blood  Influenza A H3N2 Uninfected
GSM429308 Influenza A H3N2 challenge sample at T_Flu014 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429309 Influenza A H3N2 challenge sample at baseline_Flu015 peripheral blood  Influenza A H3N2 Uninfected
GSM429310 Influenza A H3N2 challenge sample at T_Flu015 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429311 Influenza A H3N2 challenge sample at baseline_Flu016 peripheral blood  Influenza A H3N2 Uninfected
GSM429312 Influenza A H3N2 challenge sample at T_Flu016 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus
GSM429313 Influenza A H3N2 challenge sample at baseline_Flu017 peripheral blood  Influenza A H3N2 Uninfected
GSM429314 Influenza A H3N2 challenge sample at T_Flu017 peripheral blood  peak symptoms Influenza A H3N2 Influenza A virus