GSE19345

Human Cytomegalovirus Infection Causes Premature and Abnormal Differentiation of Human Neural Progenitor Cells

Submitted by Philip Hitchins Schwartz (Children's Hospital of Orange County, USA) on Dec 07 2009

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 20071566

Summary Our results suggest that HCMV infection disrupts the self-renewal capacity of NPCs and influences their differentiation.
Whole genome expression analysis revealed many changes in cellular gene expression, including downregulation of genes pertinent to the neuronal lineage.

8 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM480450	mock-infected, biological rep1	neural stem cell		mock	Uninfected
GSM480451	mock-infected, biological rep2	neural stem cell		mock	Uninfected
GSM480452	4 hours post-infection, biological rep1	neural stem cell	4 hrs	HCMV	Human betaherpesvirus 5
GSM480453	4 hours post-infection, biological rep2	neural stem cell	4 hrs	HCMV	Human betaherpesvirus 5
GSM480454	12 hours post-infection, biological rep1	neural stem cell	12 hrs	HCMV	Human betaherpesvirus 5
GSM480455	12 hours post-infection, biological rep2	neural stem cell	12 hrs	HCMV	Human betaherpesvirus 5
GSM480456	24 hours post-infection, biological rep1	neural stem cell	24 hrs	HCMV	Human betaherpesvirus 5
GSM480457	24 hours post-infection, biological rep2	neural stem cell	24 hrs	HCMV	Human betaherpesvirus 5