Virus Expression Database

GSE19345

Human Cytomegalovirus Infection Causes Premature and Abnormal Differentiation of Human Neural Progenitor Cells

Submitted by Philip Hitchins Schwartz (Children's Hospital of Orange County, USA) on Dec 07 2009

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 20071566

Summary Our results suggest that HCMV infection disrupts the self-renewal capacity of NPCs and influences their differentiation.
Whole genome expression analysis revealed many changes in cellular gene expression, including downregulation of genes pertinent to the neuronal lineage.

8 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM480450 mock-infected, biological rep1 neural stem cell  mock Uninfected
GSM480451 mock-infected, biological rep2 neural stem cell  mock Uninfected
GSM480452 4 hours post-infection, biological rep1 neural stem cell  4 hrs HCMV Human betaherpesvirus 5
GSM480453 4 hours post-infection, biological rep2 neural stem cell  4 hrs HCMV Human betaherpesvirus 5
GSM480454 12 hours post-infection, biological rep1 neural stem cell  12 hrs HCMV Human betaherpesvirus 5
GSM480455 12 hours post-infection, biological rep2 neural stem cell  12 hrs HCMV Human betaherpesvirus 5
GSM480456 24 hours post-infection, biological rep1 neural stem cell  24 hrs HCMV Human betaherpesvirus 5
GSM480457 24 hours post-infection, biological rep2 neural stem cell  24 hrs HCMV Human betaherpesvirus 5