Submitted by Rona S Scott (Louisiana State University Health Sciences Center-Shreveport, USA) on Jan 06 2010
Platform: microarray – [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Pubmed: 23891576
Summary Transition of Akata Burkitt lymphoma (BL) cells from a malignant to nonmalignant phenotype upon loss of Epstein-Barr virus (EBV) genomes in vitro is evidence for a viral contribution to tumor maintenance despite the tightly restricted pattern of EBV gene expression in BL. Akata cells retaining virus manifest increased resistance to apoptosis under growth limiting conditions, although ambiguity exists regarding the exact mechanisms involved. By examining global cellular gene expression differences in Akata subclones that had either retained or lost EBV, we identified spermidine/spermine N1-acetyltransferase (SSAT), an inducible acetylating enzyme whose catabolism of polyamines affects both apoptosis and cell growth, as one of a limited number of cellular genes up-regulated upon loss of EBV.
Keywords: Disease state analysis
ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
---|---|---|---|---|---|---|
GSM493574 | 2A8 EBV-negative Akata BL clone,4hr starve, biological rep 1 | Burkitt lymphoma cell line [Akata ] | none | Uninfected | ||
GSM493575 | 2A8 EBV-negative Akata BL clone, 4hr starve, biological rep 2 | Burkitt lymphoma cell line [Akata ] | none | Uninfected | ||
GSM493576 | 2A8 EBV-negative Akata BL clone, 4hr starve, biological rep 3 | Burkitt lymphoma cell line [Akata ] | none | Uninfected | ||
GSM493577 | 1B6 EBV-positive Akata BL clone, 4hr starve, biological rep 1 | Burkitt lymphoma cell line [Akata ] | EBV | Human gammaherpesvirus 4 | ||
GSM493578 | 1B6 EBV-positive Akata BL clone, 4hr starve, biological rep 2 | Burkitt lymphoma cell line [Akata ] | EBV | Human gammaherpesvirus 4 | ||
GSM493579 | 1B6 EBV-positive Akata BL clone, 4hr starve, biological rep 3 | Burkitt lymphoma cell line [Akata ] | EBV | Human gammaherpesvirus 4 |