Virus Expression Database
Submitted by Andrew D Yurochko (LSUHSC-S, USA) on Jan 06 2010
Platform: microarray – [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Pubmed: 20173022
Summary Human cytomegalovirus (HCMV) induces pro-inflammatory monocytes following infection and we have evidence that phosphatidylinositol 3-kinase [PI(3)K] is a key mediator in this activation. To begin to address how this signalling pathway is responsible for the functional changes in infected monocytes, we examined the role this pathway played in the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of genes were regulated in a PI(3)K-dependent manner, identifying this pathway as a key cellular control point in the conversion of monocytes to an activated pro-inflammatory state following HCMV infection.
Keywords: Disease state
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM493878 | Mock-infected monocyte, 48 hr post-infection, biological rep1 | monocyte  |
48 hrs | mock | Uninfected | |
| GSM493879 | Mock-infected monocyte, 48 hr post-infection, biological rep2 | monocyte |
48 hrs | mock | Uninfected | |
| GSM493880 | HCMV-infected monocyte, 48 hr post-infection, biological rep1 | monocyte |
48 hrs | HCMV | Human betaherpesvirus 5 | |
| GSM493881 | HCMV-infected monocyte, 48 hr post-infection, biological rep2 | monocyte |
48 hrs | HCMV | Human betaherpesvirus 5 | |
| GSM493882 | HCMV-infected/LY-pretreated monocyte, 48 hr post-infection, biological rep1 | monocyte |
48 hrs | HCMV | Human betaherpesvirus 5 | Extra interventions PI3K inhibitor |
| GSM493883 | HCMV-infected/LY-pretreated monocyte, 48 hr post-infection, biological rep2 | monocyte |
48 hrs | HCMV | Human betaherpesvirus 5 | Extra interventions PI3K inhibitor |