Virus Expression Database

GSE22522

Comparison of the transcriptome of K-LEC spheroids to control LEC spheroids

Submitted by Paive Ojala (University of Helsinki, Finland) on Jun 23 2010

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 22177562

Summary Kaposi sarcoma is the most common cancer in AIDS patients and is typified by red skin lesions.The disease is caused by the KSHV virus (HHV8) and is recognisable by its distinctive red skin lesions. The lesions are KSHV infected spindle cells expressing markers of the lymphatic endothelial and blood vessel endothelial cells as well as other cell types. The effects of KSHV infection of lymphatic endothelial cells (LEC) cultured in 3D matrix for three days were assayed using Affymetrix hgu133plus2 chips.

6 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM559251 KLECB4B7 lymphatic endothelial cell  3 days KSHV Human gammaherpesvirus 8
GSM559252 LECB4 lymphatic endothelial cell  3 days none Uninfected
GSM559253 KLECB4 lymphatic endothelial cell  3 days KSHV Human gammaherpesvirus 8
GSM559254 LECB2B7 lymphatic endothelial cell  3 days none Uninfected
GSM559255 KLECB2B7 lymphatic endothelial cell  3 days KSHV Human gammaherpesvirus 8
GSM559256 LECB4B7 lymphatic endothelial cell  3 days none Uninfected