Virus Expression Database

GSE27973

Human airway epithelial responses to rhinovirus infection and cigarette smoke extract alone and in combination

Submitted by David Proud (University of Calgary, Canada) on Mar 15 2011

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 22808255

Summary This study was performed to test the hypothesis that cigarette smoke extract would alter the responses of primary cultures of human bronchial epithelial cells to infection with purified human rhinovirus 16.
The data show marked alterations in rhinovirus-induced expression profiles of a number of genes in the presence of cigarette smoke extract (CSE).

16 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM692115 Donor 1 - medium bronchial epithelial cell  24 hrs none Uninfected
GSM692116 Donor 1 - RV16 bronchial epithelial cell  24 hrs RV16 Rhinovirus A
GSM692117 Donor 1 - CSE bronchial epithelial cell  24 hrs CSE Uninfected
GSM692118 Donor 1 - RV16+CSE bronchial epithelial cell  24 hrs RV16+CSE Rhinovirus A Extra interventions
Cigarette smoke extract
GSM692119 Donor 2 - medium bronchial epithelial cell  24 hrs none Uninfected
GSM692120 Donor 2 - RV16 bronchial epithelial cell  24 hrs RV16 Rhinovirus A
GSM692121 Donor 2 - CSE bronchial epithelial cell  24 hrs CSE Uninfected
GSM692122 Donor 2 - RV16+CSE bronchial epithelial cell  24 hrs RV16+CSE Rhinovirus A Extra interventions
Cigarette smoke extract
GSM692123 Donor 3 - medium bronchial epithelial cell  24 hrs none Uninfected
GSM692124 Donor 3 - RV16 bronchial epithelial cell  24 hrs RV16 Rhinovirus A
GSM692125 Donor 3 - CSE bronchial epithelial cell  24 hrs CSE Uninfected
GSM692126 Donor 3 - RV16+CSE bronchial epithelial cell  24 hrs RV16+CSE Rhinovirus A Extra interventions
Cigarette smoke extract
GSM692127 Donor 4 - medium bronchial epithelial cell  24 hrs none Uninfected
GSM692128 Donor 4 - RV16 bronchial epithelial cell  24 hrs RV16 Rhinovirus A
GSM692129 Donor 4 - CSE bronchial epithelial cell  24 hrs CSE Uninfected
GSM692130 Donor 4 - RV16+CSE bronchial epithelial cell  24 hrs RV16+CSE Rhinovirus A