GSE34628

Gene expression timecourse from Dengue virus infected human endothelial cells

Submitted by Nadine Dalrymple (Stony Brook University, USA) on Dec 21 2011

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 22496214

Summary Dengue viruses cause two severe diseases that alter vascular fluid barrier functions, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). While the mechanisms that lead to vascular permeability are unknown, the endothelium plays a central role in regulating fluid and cellular efflux from capillaries. Thus, dysregulation of endothelial cells functions by dengue virus infection may contribute to pathogenesis and severe disease.
We used microarrays to investigate the effect of dengue virus infection on gene expression within primary human endothelial cells at various times post infection and identified numerous upregulated antiviral and immune response genes.

6 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM852161	DV infected ECs at 12 hours	umbilical vein endothelial cell line	12 hrs	DV	Dengue virus
GSM852162	Mock infected ECs at 12 hours	umbilical vein endothelial cell line	12 hrs	Mock	Uninfected
GSM852163	DV infected ECs at 24 hours	umbilical vein endothelial cell line	24 hrs	DV	Dengue virus
GSM852164	Mock infected ECs at 24 hours	umbilical vein endothelial cell line	24 hrs	Mock	Uninfected
GSM852165	DV infected ECs at 48 hours	umbilical vein endothelial cell line	48 hrs	DV	Dengue virus
GSM852166	Mock infected ECs at 48 hours	umbilical vein endothelial cell line	48 hrs	Mock	Uninfected