Virus Expression Database

GSE47199

Expression data from blood and biopsies of BKV viremia and nephropathy transplant patients

Submitted by Pilib Ó Broin (Albert Einstein College of Medicine, USA) on May 22 2013

Platform: microarray – [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

Pubmed: 24310299

Summary We study the global gene expression profiles of BKV viremia and nephropathy patients using microarrays in order to better understand the immunologic response to polyomavirus BK (BKV).
BKV has become increasingly prevalent since the introduction of more potent immunosuppressive agents. It has been shown that as many as 30% of renal transplant recipients develop asymptomatic viral shedding in the urine shortly after transplant, 10-20% have viremia, and as many as 1-10% can go on to develop overt nephropathy (BKVN) that might lead to graft loss. To date, the genomics of BKV viremia and BKVN have not been investigated thoroughly by microarray.

57 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM1146679 Blood_BKV_1 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146680 Blood_BKV_2 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146681 Blood_BKV_3 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146682 Blood_BKV_4 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146683 Blood_BKV_5 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146684 Blood_BKV_6 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146685 Blood_BKV_7 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146686 Blood_BKV_8 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146687 Blood_Control_1 peripheral blood  control Uninfected
GSM1146688 Blood_PreBKV_1 peripheral blood  pre-BKV Uninfected
GSM1146689 Blood_Control_2 peripheral blood  control Uninfected
GSM1146690 Blood_PreBKV_2 peripheral blood  pre-BKV Uninfected
GSM1146691 Blood_BKV_9 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146692 Blood_Control_3 peripheral blood  control Uninfected
GSM1146693 Blood_Control_4 peripheral blood  control Uninfected
GSM1146694 Blood_PreBKV_3 peripheral blood  pre-BKV Uninfected
GSM1146695 Blood_BKV_10 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146696 Blood_BKV_11 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146697 Blood_PreBKV_4 peripheral blood  pre-BKV Uninfected
GSM1146698 Blood_BKV_12 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146699 Blood_Control_5 peripheral blood  control Uninfected
GSM1146700 Blood_PreBKV_5 peripheral blood  pre-BKV Uninfected
GSM1146701 Blood_BKV_13 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146702 Blood_BKV_14 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146703 Blood_PreBKV_6 peripheral blood  pre-BKV Uninfected
GSM1146704 Blood_Control_6 peripheral blood  control Uninfected
GSM1146705 Blood_Control_7 peripheral blood  control Uninfected
GSM1146706 Blood_Control_8 peripheral blood  control Uninfected
GSM1146707 Blood_Control_9 peripheral blood  control Uninfected
GSM1146708 Blood_BKV_15 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146709 Blood_Control_10 peripheral blood  control Uninfected
GSM1146710 Blood_Control_11 peripheral blood  control Uninfected Data failed QC
all_probeset_mad_residual_mean is 0.815043 (poor normalization, above threshold of 0.80)
GSM1146711 Blood_Control_12 peripheral blood  control Uninfected
GSM1146712 Blood_BKV_16 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146713 Blood_BKV_17 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146714 Blood_Control_13 peripheral blood  control Uninfected
GSM1146715 Blood_BKV_18 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146716 Blood_PreBKV_7 peripheral blood  pre-BKV Uninfected
GSM1146717 Blood_Control_14 peripheral blood  control Uninfected
GSM1146718 Blood_BKV_19 peripheral blood  chronic BKV Human polyomavirus 1
GSM1146719 Biopsy_Normal_1 kidney  normal Uninfected
GSM1146720 Biopsy_Normal_2 kidney  normal Uninfected
GSM1146721 Biopsy_BKVN_1 kidney  chronic BKV Human polyomavirus 1 Extra interventions
nephropathy
GSM1146722 Biopsy_BKVN_2 kidney  chronic BKV Human polyomavirus 1 Extra interventions
nephropathy
GSM1146723 Biopsy_Normal_3 kidney  normal Uninfected
GSM1146724 Biopsy_Normal_4 kidney  normal Uninfected
GSM1146725 Biopsy_Normal_5 kidney  normal Uninfected
GSM1146726 Biopsy_Normal_6 kidney  normal Uninfected
GSM1146727 Biopsy_BKVpos_1 kidney  chronic BKV Human polyomavirus 1
GSM1146728 Biopsy_Normal_7 kidney  normal Uninfected
GSM1146729 Biopsy_Normal_8 kidney  normal Uninfected
GSM1146730 Biopsy_BKVN_3 kidney  chronic BKV Human polyomavirus 1 Extra interventions
nephropathy
GSM1146731 Biopsy_Normal_9 kidney  normal Uninfected
GSM1146732 Biopsy_Normal_10 kidney  normal Uninfected
GSM1146733 Biopsy_Normal_11 kidney  normal Uninfected
GSM1146734 Biopsy_BKVpos_2 kidney  chronic BKV Human polyomavirus 1
GSM1146735 Biopsy_BKVpos_3 kidney  chronic BKV Human polyomavirus 1