Virus Expression Database

GSE49628

Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization [Expression Array]

Submitted by Kasper Daniel Hansen (Johns Hopkins, USA) on Aug 07 2013

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 24068705, 25599564

Summary To determine what DNA methylation and gene expression changes occur following EBV transformation. B-cells were isolated from 3 donors. Resting, CD40 activated and EBV transfromed cells from each donor was analyzed. Each sample was assayed using Affymetrix expression arrays and whole genome bisulfite sequenicng. Additional time points during transformation and activation were sequenced as well, but not assayed for expression.

9 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM1202819 Bcells-Activation-B1 B-lymphocyte  uninfected Uninfected Extra interventions
CD40 activated
GSM1202820 Bcells-Quiescent-B1 B-lymphocyte  uninfected Uninfected
GSM1202821 Bcells-EBV_Transformed_B1 B-lymphocyte  EBV Human gammaherpesvirus 4
GSM1202822 Bcells-Activation-B2 B-lymphocyte  uninfected Uninfected Extra interventions
CD40 activated
GSM1202823 Bcells-Quiescent-B2 B-lymphocyte  uninfected Uninfected
GSM1202824 Bcells-EBV_Transformed_B2 B-lymphocyte  EBV Human gammaherpesvirus 4
GSM1202825 Bcells-Activation-B3 B-lymphocyte  uninfected Uninfected Extra interventions
CD40 activated
GSM1202826 Bcells-Quiescent-B3 B-lymphocyte  uninfected Uninfected
GSM1202827 Bcells-EBV_Transformed_B3 B-lymphocyte  EBV Human gammaherpesvirus 4