GSE49628

Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization [Expression Array]

Submitted by Kasper Daniel Hansen (Johns Hopkins, USA) on Aug 07 2013

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 24068705, 25599564

Summary To determine what DNA methylation and gene expression changes occur following EBV transformation. B-cells were isolated from 3 donors. Resting, CD40 activated and EBV transfromed cells from each donor was analyzed. Each sample was assayed using Affymetrix expression arrays and whole genome bisulfite sequenicng. Additional time points during transformation and activation were sequenced as well, but not assayed for expression.

9 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM1202819	Bcells-Activation-B1	B-lymphocyte		uninfected	Uninfected	Extra interventions CD40 activated
GSM1202820	Bcells-Quiescent-B1	B-lymphocyte		uninfected	Uninfected
GSM1202821	Bcells-EBV_Transformed_B1	B-lymphocyte		EBV	Human gammaherpesvirus 4
GSM1202822	Bcells-Activation-B2	B-lymphocyte		uninfected	Uninfected	Extra interventions CD40 activated
GSM1202823	Bcells-Quiescent-B2	B-lymphocyte		uninfected	Uninfected
GSM1202824	Bcells-EBV_Transformed_B2	B-lymphocyte		EBV	Human gammaherpesvirus 4
GSM1202825	Bcells-Activation-B3	B-lymphocyte		uninfected	Uninfected	Extra interventions CD40 activated
GSM1202826	Bcells-Quiescent-B3	B-lymphocyte		uninfected	Uninfected
GSM1202827	Bcells-EBV_Transformed_B3	B-lymphocyte		EBV	Human gammaherpesvirus 4