GSE50938

Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication

Submitted by Jiri Zavadil (NYU SoM, USA) on Sep 17 2013

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 24373965

Summary Genome-wide profiling establishes that human cytomegalovirus (HCMV) exerts an extensive, unforeseen level of specific control over which cellular mRNAs are recruited to or excluded from polyribosomes.
The landscape of translationally-regulated host mRNAs regulates HCMV replication. The HCMV imposed translational signature shares similarities with cancer cells

16 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM1232755	extracted total RNA, uninfected NHDFs (normal human dermal fibroblasts) rep1	dermal fibroblast		uninfected	Uninfected
GSM1232756	extracted total RNA, uninfected NHDFs (normal human dermal fibroblasts) rep2	dermal fibroblast		uninfected	Uninfected
GSM1232757	extracted total RNA, HCMV-infected NHDFs, 48 hr post-infection rep1	dermal fibroblast	48 hrs	HCMV	Human betaherpesvirus 5
GSM1232758	extracted total RNA, HCMV-infected NHDFs, 48 hr post-infection rep2	dermal fibroblast	48 hrs	HCMV	Human betaherpesvirus 5
GSM1232759	polysomal RNA, uninfected NHDFs rep1	dermal fibroblast		uninfected	Uninfected	Extra interventions polysomal RNA
GSM1232760	polysomal RNA, uninfected NHDFs rep2	dermal fibroblast		uninfected	Uninfected	Extra interventions polysomal RNA
GSM1232761	polysomal RNA, HCMV-infected NHDFs, 48 hr post-infection rep1	dermal fibroblast	48 hrs	HCMV	Human betaherpesvirus 5	Extra interventions polysomal RNA
GSM1232762	polysomal RNA, HCMV-infected NHDFs, 48 hr post-infection rep2	dermal fibroblast	48 hrs	HCMV	Human betaherpesvirus 5	Extra interventions polysomal RNA
GSM1232763	extracted total RNA ,uninduced NHDFs rep1	dermal fibroblast		uninfected	Uninfected
GSM1232764	extracted total RNA, uninduced NHDFs rep2	dermal fibroblast		uninfected	Uninfected
GSM1232765	extracted total RNA, UL38-induced, 48 hr post-induction rep1	dermal fibroblast		uninfected	Uninfected	Extra interventions HCMV protein
GSM1232766	extracted total RNA, UL38-induced, 48 hr post-induction rep2	dermal fibroblast		uninfected	Uninfected	Extra interventions HCMV protein
GSM1232767	polysomal RNA, uninduced NHDFs rep1	dermal fibroblast		uninfected	Uninfected	Extra interventions polysomal RNA
GSM1232768	polysomal RNA, uninduced NHDFs rep2	dermal fibroblast		uninfected	Uninfected	Extra interventions polysomal RNA
GSM1232769	polysomal RNA, UL38-induced NHDFs, 48 hr post-induction rep1	dermal fibroblast		uninfected	Uninfected	Extra interventions polysomal RNA; HCMV protein
GSM1232770	polysomal RNA, UL38-induced NHDFs, 48 hr post-induction rep2	dermal fibroblast		uninfected	Uninfected	Extra interventions polysomal RNA; HCMV protein