Virus Expression Database

GSE50938

Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication

Submitted by Jiri Zavadil (NYU SoM, USA) on Sep 17 2013

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 24373965

Summary Genome-wide profiling establishes that human cytomegalovirus (HCMV) exerts an extensive, unforeseen level of specific control over which cellular mRNAs are recruited to or excluded from polyribosomes.
The landscape of translationally-regulated host mRNAs regulates HCMV replication. The HCMV imposed translational signature shares similarities with cancer cells

16 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM1232755 extracted total RNA, uninfected NHDFs (normal human dermal fibroblasts) rep1 dermal fibroblast  uninfected Uninfected
GSM1232756 extracted total RNA, uninfected NHDFs (normal human dermal fibroblasts) rep2 dermal fibroblast  uninfected Uninfected
GSM1232757 extracted total RNA, HCMV-infected NHDFs, 48 hr post-infection rep1 dermal fibroblast  48 hrs HCMV Human betaherpesvirus 5
GSM1232758 extracted total RNA, HCMV-infected NHDFs, 48 hr post-infection rep2 dermal fibroblast  48 hrs HCMV Human betaherpesvirus 5
GSM1232759 polysomal RNA, uninfected NHDFs rep1 dermal fibroblast  uninfected Uninfected Extra interventions
polysomal RNA
GSM1232760 polysomal RNA, uninfected NHDFs rep2 dermal fibroblast  uninfected Uninfected Extra interventions
polysomal RNA
GSM1232761 polysomal RNA, HCMV-infected NHDFs, 48 hr post-infection rep1 dermal fibroblast  48 hrs HCMV Human betaherpesvirus 5 Extra interventions
polysomal RNA
GSM1232762 polysomal RNA, HCMV-infected NHDFs, 48 hr post-infection rep2 dermal fibroblast  48 hrs HCMV Human betaherpesvirus 5 Extra interventions
polysomal RNA
GSM1232763 extracted total RNA ,uninduced NHDFs rep1 dermal fibroblast  uninfected Uninfected
GSM1232764 extracted total RNA, uninduced NHDFs rep2 dermal fibroblast  uninfected Uninfected
GSM1232765 extracted total RNA, UL38-induced, 48 hr post-induction rep1 dermal fibroblast  uninfected Uninfected Extra interventions
HCMV protein
GSM1232766 extracted total RNA, UL38-induced, 48 hr post-induction rep2 dermal fibroblast  uninfected Uninfected Extra interventions
HCMV protein
GSM1232767 polysomal RNA, uninduced NHDFs rep1 dermal fibroblast  uninfected Uninfected Extra interventions
polysomal RNA
GSM1232768 polysomal RNA, uninduced NHDFs rep2 dermal fibroblast  uninfected Uninfected Extra interventions
polysomal RNA
GSM1232769 polysomal RNA, UL38-induced NHDFs, 48 hr post-induction rep1 dermal fibroblast  uninfected Uninfected Extra interventions
polysomal RNA; HCMV protein
GSM1232770 polysomal RNA, UL38-induced NHDFs, 48 hr post-induction rep2 dermal fibroblast  uninfected Uninfected Extra interventions
polysomal RNA; HCMV protein