Virus Expression Database
Submitted by You-Wen He (Duke University, USA) on Oct 21 2013
Platform: microarray – [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Pubmed: 26199080
Summary The low frequency of HBV-specific CD8+ T cells in the peripheral blood of CHB patients has limited studies of the mechanisms underlying HBV-induced T cell exhaustion. Similar to the expansion defect displayed in HBV-specific CD8+ T cells, TCR-induced proliferation of global CD8+ T cells is impaired in a fraction of chronic HBV (CHB) patients. Thus, examining the molecular regulation of global CD8+ T cell function in CHB patients may provide insight into the exhaustion of HBV-specific CD8+ T cells.
We used microarrays to detail the global programme of gene expression of CD8 T cells from CHB patients who have not received anti-viral treatment.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM1246448 | Healthy control 1 | cytotoxic T-lymphocyte  |
healthy | Uninfected | ||
| GSM1246449 | Healthy control 2 | cytotoxic T-lymphocyte |
healthy | Uninfected | ||
| GSM1246450 | Healthy control 3 | cytotoxic T-lymphocyte |
healthy | Uninfected | ||
| GSM1246451 | CHB 1 | cytotoxic T-lymphocyte |
chronic | HBV | Hepatitis B virus | |
| GSM1246452 | CHB 2 | cytotoxic T-lymphocyte |
chronic | HBV | Hepatitis B virus | |
| GSM1246453 | CHB 3 | cytotoxic T-lymphocyte |
chronic | HBV | Hepatitis B virus |