Virus Expression Database

GSE51489

mRNA profile of CD8 T cells from chronic HBV patients

Submitted by You-Wen He (Duke University, USA) on Oct 21 2013

Platform: microarray – [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

Pubmed: 26199080

Summary The low frequency of HBV-specific CD8+ T cells in the peripheral blood of CHB patients has limited studies of the mechanisms underlying HBV-induced T cell exhaustion. Similar to the expansion defect displayed in HBV-specific CD8+ T cells, TCR-induced proliferation of global CD8+ T cells is impaired in a fraction of chronic HBV (CHB) patients. Thus, examining the molecular regulation of global CD8+ T cell function in CHB patients may provide insight into the exhaustion of HBV-specific CD8+ T cells.
We used microarrays to detail the global programme of gene expression of CD8 T cells from CHB patients who have not received anti-viral treatment.

6 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM1246448 Healthy control 1 cytotoxic T-lymphocyte  healthy Uninfected
GSM1246449 Healthy control 2 cytotoxic T-lymphocyte  healthy Uninfected
GSM1246450 Healthy control 3 cytotoxic T-lymphocyte  healthy Uninfected
GSM1246451 CHB 1 cytotoxic T-lymphocyte  chronic HBV Hepatitis B virus
GSM1246452 CHB 2 cytotoxic T-lymphocyte  chronic HBV Hepatitis B virus
GSM1246453 CHB 3 cytotoxic T-lymphocyte  chronic HBV Hepatitis B virus