Virus Expression Database

GSE53731

Expression data from hepatitis E virus inoculated PLC/PRF/5 cells

Submitted by Feng Zhang (National Institutre for Food and Drug Control, China) on Dec 30 2013

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 25042677

Summary Hepatitis E virus (HEV) is an important causative pathogen of acute hepatitis. Because of the absence of an in vitro culture system for HEV, research has been greatly impeded. And interaction between HEV and host cells was mainly studied by tansfection/transinfection system, such as Adeno virus transinfection system. We developed an in vitro culture system for HEV in PLC/PRF/5 cells. With this in vitro culture system, we studied the gene expression profile change by HEV infection.
Using a microarray assay, we analysed genes of PLC/PRF/5 cells, whose transcription level could be changed by HEV infection.

10 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM1299471 HEV inoculated PLC/PRF/5, Rep1 hepatoma cell line  [PLC/PRF/5 ] 60 days HEV Orthohepevirus A
GSM1299472 HEV inoculated PLC/PRF/5, Rep2 hepatoma cell line  [PLC/PRF/5 ] 60 days HEV Orthohepevirus A
GSM1299473 HEV inoculated PLC/PRF/5, Rep3 hepatoma cell line  [PLC/PRF/5 ] 60 days HEV Orthohepevirus A
GSM1299474 HEV inoculated PLC/PRF/5, Rep4 hepatoma cell line  [PLC/PRF/5 ] 60 days HEV Orthohepevirus A
GSM1299475 HEV inoculated PLC/PRF/5, Rep5 hepatoma cell line  [PLC/PRF/5 ] 60 days HEV Orthohepevirus A
GSM1299476 Control PLC/PRF/5, Rep1 hepatoma cell line  [PLC/PRF/5 ] 60 days control Uninfected
GSM1299477 Control PLC/PRF/5, Rep2 hepatoma cell line  [PLC/PRF/5 ] 60 days control Uninfected
GSM1299478 Control PLC/PRF/5, Rep3 hepatoma cell line  [PLC/PRF/5 ] 60 days control Uninfected
GSM1299479 Control PLC/PRF/5, Rep4 hepatoma cell line  [PLC/PRF/5 ] 60 days control Uninfected
GSM1299480 Control PLC/PRF/5, Rep5 hepatoma cell line  [PLC/PRF/5 ] 60 days control Uninfected