GSE53731

Expression data from hepatitis E virus inoculated PLC/PRF/5 cells

Submitted by Feng Zhang (National Institutre for Food and Drug Control, China) on Dec 30 2013

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 25042677

Summary Hepatitis E virus (HEV) is an important causative pathogen of acute hepatitis. Because of the absence of an in vitro culture system for HEV, research has been greatly impeded. And interaction between HEV and host cells was mainly studied by tansfection/transinfection system, such as Adeno virus transinfection system. We developed an in vitro culture system for HEV in PLC/PRF/5 cells. With this in vitro culture system, we studied the gene expression profile change by HEV infection.
Using a microarray assay, we analysed genes of PLC/PRF/5 cells, whose transcription level could be changed by HEV infection.

10 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM1299471	HEV inoculated PLC/PRF/5, Rep1	hepatoma cell line  [PLC/PRF/5 ]	60 days	HEV	Orthohepevirus A
GSM1299472	HEV inoculated PLC/PRF/5, Rep2	hepatoma cell line  [PLC/PRF/5 ]	60 days	HEV	Orthohepevirus A
GSM1299473	HEV inoculated PLC/PRF/5, Rep3	hepatoma cell line  [PLC/PRF/5 ]	60 days	HEV	Orthohepevirus A
GSM1299474	HEV inoculated PLC/PRF/5, Rep4	hepatoma cell line  [PLC/PRF/5 ]	60 days	HEV	Orthohepevirus A
GSM1299475	HEV inoculated PLC/PRF/5, Rep5	hepatoma cell line  [PLC/PRF/5 ]	60 days	HEV	Orthohepevirus A
GSM1299476	Control PLC/PRF/5, Rep1	hepatoma cell line  [PLC/PRF/5 ]	60 days	control	Uninfected
GSM1299477	Control PLC/PRF/5, Rep2	hepatoma cell line  [PLC/PRF/5 ]	60 days	control	Uninfected
GSM1299478	Control PLC/PRF/5, Rep3	hepatoma cell line  [PLC/PRF/5 ]	60 days	control	Uninfected
GSM1299479	Control PLC/PRF/5, Rep4	hepatoma cell line  [PLC/PRF/5 ]	60 days	control	Uninfected
GSM1299480	Control PLC/PRF/5, Rep5	hepatoma cell line  [PLC/PRF/5 ]	60 days	control	Uninfected