Virus Expression Database

GSE58994

Expression data from primary human leukocytes (peropheral blood mononuclear cells, PBMC) cultured in vitro with HIV-1MN, HIV-2NIH-Z, CpG-A ODN or media alone

Submitted by Adriano Boasso (Imperial College London, United Kingdom) on Jul 01 2014

Platform: microarray – [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]

Pubmed: 25156368

Summary HIV-1 and HIV-2 can both infect humans, but HIV-2 causes a slow progressing disease and is well controlled by the immune system for prolonged period of times.
Here we tested acute response aainst HIV-1 and HIV-2 exposure in peripheral blood mononuclear cells (PBMC) from three indepednent donors.

24 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM1423557 PBMC from Donor A at 6h in Media peripheral blood mononuclear cell  6 hrs media Uninfected
GSM1423558 PBMC from Donor A at 6h with HIV-1 peripheral blood mononuclear cell  6 hrs HIV-1 Human immunodeficiency virus 1
GSM1423559 PBMC from Donor A at 6h with HIV-2 peripheral blood mononuclear cell  6 hrs HIV-2 Human immunodeficiency virus 2
GSM1423560 PBMC from Donor A at 6h with CpG-A peripheral blood mononuclear cell  6 hrs CpG-A Uninfected Extra interventions
CpG-A is a TLR-9 agonist
GSM1423561 PBMC from Donor B at 6h in Media peripheral blood mononuclear cell  6 hrs media Uninfected
GSM1423562 PBMC from Donor B at 6h with HIV-1 peripheral blood mononuclear cell  6 hrs HIV-1 Human immunodeficiency virus 1
GSM1423563 PBMC from Donor B at 6h with HIV-2 peripheral blood mononuclear cell  6 hrs HIV-2 Human immunodeficiency virus 2
GSM1423564 PBMC from Donor B at 6h with CpG-A peripheral blood mononuclear cell  6 hrs CpG-A Uninfected Extra interventions
CpG-A is a TLR-9 agonist
GSM1423565 PBMC from Donor C at 6h in Media peripheral blood mononuclear cell  6 hrs media Uninfected
GSM1423566 PBMC from Donor C at 6h with HIV-1 peripheral blood mononuclear cell  6 hrs HIV-1 Human immunodeficiency virus 1
GSM1423567 PBMC from Donor C at 6h with HIV-2 peripheral blood mononuclear cell  6 hrs HIV-2 Human immunodeficiency virus 2
GSM1423568 PBMC from Donor C at 6h with CpG-A peripheral blood mononuclear cell  6 hrs CpG-A Uninfected Extra interventions
CpG-A is a TLR-9 agonist
GSM1423569 PBMC from Donor A at 12h in Media peripheral blood mononuclear cell  12 hrs media Uninfected
GSM1423570 PBMC from Donor A at 12h with HIV-1 peripheral blood mononuclear cell  12 hrs HIV-1 Human immunodeficiency virus 1
GSM1423571 PBMC from Donor A at 12h with HIV-2 peripheral blood mononuclear cell  12 hrs HIV-2 Human immunodeficiency virus 2
GSM1423572 PBMC from Donor A at 12h with CpG-A peripheral blood mononuclear cell  12 hrs CpG-A Uninfected Extra interventions
CpG-A is a TLR-9 agonist
GSM1423573 PBMC from Donor B at 12h in Media peripheral blood mononuclear cell  12 hrs media Uninfected
GSM1423574 PBMC from Donor B at 12h with HIV-1 peripheral blood mononuclear cell  12 hrs HIV-1 Human immunodeficiency virus 1
GSM1423575 PBMC from Donor B at 12h with HIV-2 peripheral blood mononuclear cell  12 hrs HIV-2 Human immunodeficiency virus 2
GSM1423576 PBMC from Donor B at 12h with CpG-A peripheral blood mononuclear cell  12 hrs CpG-A Uninfected Extra interventions
CpG-A is a TLR-9 agonist
GSM1423577 PBMC from Donor C at 12h in Media peripheral blood mononuclear cell  12 hrs media Uninfected
GSM1423578 PBMC from Donor C at 12h with HIV-1 peripheral blood mononuclear cell  12 hrs HIV-1 Human immunodeficiency virus 1
GSM1423579 PBMC from Donor C at 12h with HIV-2 peripheral blood mononuclear cell  12 hrs HIV-2 Human immunodeficiency virus 2
GSM1423580 PBMC from Donor C at 12h with CpG-A peripheral blood mononuclear cell  12 hrs CpG-A Uninfected Extra interventions
CpG-A is a TLR-9 agonist