GSE73853

Transcriptome analysis of diverse cell types infected with human cytomegalovirus [RNA-Seq]

Submitted by Gene Yeo (UCSD, USA) on Sep 08 2016

Platform: ngs – Illumina HiSeq 2000 (Homo sapiens)

Pubmed: 27775709

Summary Comprehensive RNA sequencing and splicing-sensitive microarray analysis of three diverse cell types infected with human cytomegalovirus (HCMV), including primary fibroblasts (HFFs), endothelial cells (ECs), and neural progenitors (NPCs) derived from embryonic stem cells. This global analysis includes both host and viral gene expression measurements, and an in-depth assessment of alternative RNA processing events. Extended comparisons were conducted through RNA sequencing analysis of human herpes simplex virus (HSV)-2 and human immunodeficiency virus type 1 (HIV-1) infections.

13 Samples

ID	Title	Cell Type	Timepoint	Reported Virus	Virus Species	Exclusion Reason
GSM1904488	HFF_Mock_48h	foreskin fibroblast cell line	48 hrs	mock	Uninfected
GSM1904489	HFF_InfectedHCMVTB40E_48h	foreskin fibroblast cell line	48 hrs	HCMV	Human betaherpesvirus 5
GSM1904490	HFF_InfectedHCMVTB40E_96h	foreskin fibroblast cell line	96 hrs	HCMV	Human betaherpesvirus 5
GSM1904491	EC_Mock_48h	endothelial cell	48 hrs	mock	Uninfected
GSM1904492	EC_InfectedHCMVTB40E_48h	endothelial cell	48 hrs	HCMV	Human betaherpesvirus 5
GSM1904493	EC_InfectedHCMVTB40E_96h	endothelial cell	96 hrs	HCMV	Human betaherpesvirus 5
GSM1904494	NPC_Mock_48h	neural stem cell	48 hrs	mock	Uninfected
GSM1904495	NPC_InfectedHCMVTB40E_48h	neural stem cell	48 hrs	HCMV	Human betaherpesvirus 5
GSM1904496	NPC_InfectedHCMVTB40E_96h	neural stem cell	96 hrs	HCMV	Human betaherpesvirus 5
GSM1904497	HFF_MockforHSV_8h	foreskin fibroblast cell line	8 hrs	mock	Uninfected
GSM1904498	HFF_InfectedHSV2_8h	foreskin fibroblast cell line	8 hrs	HSV-2	Human alphaherpesvirus 2
GSM2306702	Tcell_Control_5d	T-lymphocyte	5 days	control	Uninfected
GSM2306703	Tcell_InfectedHIV1_5d	T-lymphocyte	5 days	HIV-1	Human immunodeficiency virus 1