Virus Expression Database

GSE77154

IFNγ influences epithelial anti-viral responses via histone methylation of the RIG-I promoter

Submitted by Akul Singhania (The Francis Crick Institute, United Kingdom) on Jan 22 2016

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 28481620

Summary This in-vitro study suggests the inflammatory environment of naive epithelial cells can induce epigenetic modulation of innate immune responses at the level of histone methylation and potentially lead to long-term impacts on anti-viral immunity.

8 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM2044944 Control sample, rep 1 bronchial epithelial cell line  [AALEB ] none Uninfected
GSM2044945 Control sample, rep 2 bronchial epithelial cell line  [AALEB ] none Uninfected
GSM2044946 IFNγ only sample, rep 1 bronchial epithelial cell line  [AALEB ] none Uninfected Extra interventions
IFN gamma added
GSM2044947 IFNγ only sample, rep 2 bronchial epithelial cell line  [AALEB ] none Uninfected Extra interventions
IFN gamma added
GSM2044948 RSV only sample, rep 1 bronchial epithelial cell line  [AALEB ] 48 hrs RSV subtype A Memphis 37 Human orthopneumovirus
GSM2044949 RSV only sample, rep 2 bronchial epithelial cell line  [AALEB ] 48 hrs RSV subtype A Memphis 37 Human orthopneumovirus
GSM2044950 RSV & IFNγ sample, rep 1 bronchial epithelial cell line  [AALEB ] 48 hrs RSV subtype A Memphis 37 Human orthopneumovirus Extra interventions
IFN gamma added
GSM2044951 RSV & IFNγ sample, rep 2 bronchial epithelial cell line  [AALEB ] 48 hrs RSV subtype A Memphis 37 Human orthopneumovirus Extra interventions
IFN gamma added