Virus Expression Database
Submitted by Peng Jin (Emory University, USA) on Apr 19 2016
Platform: ngs – Illumina HiSeq 2000 (Homo sapiens)
Pubmed: 27580721
Summary Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function remains elusive. Here we systematically profiled transcriptomes of human neural progenitor cells (hNPCs) exposed to Asian ZIKVC, African ZIKVM, and Dengue virus (DENV). DENV causes distinct gene expression changes; and ZIKV has a broader impact on the expression of gene involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. Further investigation of ZIKV-host interactions based our transcriptomic datasets may help to illuminate neural virulence determinants of ZIKV in patients.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM2127237 | RNAseq-NPC-DENV-1 | neural stem cell  |
unknown | DENV | Dengue virus | |
| GSM2127238 | RNAseq-NPC-DENV-2 | neural stem cell |
unknown | DENV | Dengue virus | |
| GSM2127239 | RNAseq-NPC-DENV-3 | neural stem cell |
unknown | DENV | Dengue virus | |
| GSM2127240 | RNAseq-NPC-DENV-Mock-1 | neural stem cell |
mock | Uninfected | ||
| GSM2127241 | RNAseq-NPC-DENV-Mock-2 | neural stem cell |
mock | Uninfected | ||
| GSM2127242 | RNAseq-NPC-DENV-Mock-3 | neural stem cell |
mock | Uninfected | ||
| GSM2127243 | RNAseq-NPC-ZIKVC-1 | neural stem cell |
unknown | Asian ZIKVC | Zika virus | |
| GSM2127244 | RNAseq-NPC-ZIKVC-2 | neural stem cell |
unknown | Asian ZIKVC | Zika virus | |
| GSM2127245 | RNAseq-NPC-Mock-1 | neural stem cell |
mock | Uninfected | ||
| GSM2127246 | RNAseq-NPC-Mock-2 | neural stem cell |
mock | Uninfected | ||
| GSM2127247 | RNAseq-NPC-Mock-3 | neural stem cell |
mock | Uninfected | ||
| GSM2127248 | RNAseq-NPC-Mock-4 | neural stem cell |
mock | Uninfected | ||
| GSM2127249 | RNAseq-NPC-ZIKVM-1 | neural stem cell |
unknown | African ZIKVM | Zika virus | |
| GSM2127250 | RNAseq-NPC-ZIKVM-2 | neural stem cell |
unknown | African ZIKVM | Zika virus | |
| GSM2127251 | RNAseq-NPC-ZIKVM-3 | neural stem cell |
unknown | African ZIKVM | Zika virus | |
| GSM2127252 | RNAseq-NPC-ZIKVM-4 | neural stem cell |
unknown | African ZIKVM | Zika virus |