Virus Expression Database

GSE80434

Molecular Signatures Associated with ZIKV Exposure in Human Cortical Neural Progenitors

Submitted by Peng Jin (Emory University, USA) on Apr 19 2016

Platform: ngs – Illumina HiSeq 2000 (Homo sapiens)

Pubmed: 27580721

Summary Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function remains elusive. Here we systematically profiled transcriptomes of human neural progenitor cells (hNPCs) exposed to Asian ZIKVC, African ZIKVM, and Dengue virus (DENV). DENV causes distinct gene expression changes; and ZIKV has a broader impact on the expression of gene involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. Further investigation of ZIKV-host interactions based our transcriptomic datasets may help to illuminate neural virulence determinants of ZIKV in patients.

16 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM2127237 RNAseq-NPC-DENV-1 neural stem cell  unknown DENV Dengue virus
GSM2127238 RNAseq-NPC-DENV-2 neural stem cell  unknown DENV Dengue virus
GSM2127239 RNAseq-NPC-DENV-3 neural stem cell  unknown DENV Dengue virus
GSM2127240 RNAseq-NPC-DENV-Mock-1 neural stem cell  mock Uninfected
GSM2127241 RNAseq-NPC-DENV-Mock-2 neural stem cell  mock Uninfected
GSM2127242 RNAseq-NPC-DENV-Mock-3 neural stem cell  mock Uninfected
GSM2127243 RNAseq-NPC-ZIKVC-1 neural stem cell  unknown Asian ZIKVC Zika virus
GSM2127244 RNAseq-NPC-ZIKVC-2 neural stem cell  unknown Asian ZIKVC Zika virus
GSM2127245 RNAseq-NPC-Mock-1 neural stem cell  mock Uninfected
GSM2127246 RNAseq-NPC-Mock-2 neural stem cell  mock Uninfected
GSM2127247 RNAseq-NPC-Mock-3 neural stem cell  mock Uninfected
GSM2127248 RNAseq-NPC-Mock-4 neural stem cell  mock Uninfected
GSM2127249 RNAseq-NPC-ZIKVM-1 neural stem cell  unknown African ZIKVM Zika virus
GSM2127250 RNAseq-NPC-ZIKVM-2 neural stem cell  unknown African ZIKVM Zika virus
GSM2127251 RNAseq-NPC-ZIKVM-3 neural stem cell  unknown African ZIKVM Zika virus
GSM2127252 RNAseq-NPC-ZIKVM-4 neural stem cell  unknown African ZIKVM Zika virus