Virus Expression Database

GSE83259

High-risk human papillomavirus E7 affects host keratinocyte gene expression

Submitted by Dohun Pyeon (University of Colorado School of Medicine, USA) on Jun 13 2016

Platform: microarray – [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

Pubmed: 28623356

Summary To investigate the extent of gene expression dysregulation by the human papillomavirus (HPV) oncoprotein E7, we performed global gene expression analysis on normal immortalized keratinocytes from skin (NIKS),
NIKS cells maintaining the HPV16 or 18 episomes (NIKS-16, NIKS-18, respectively), and NIKS cells maintaining the HPV-16 episome deficient in E7 expression (NIKS-16ΔE7).

12 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM2197772 NIKS replicate 1 keratinocyte cell line  Uninfected
GSM2197773 NIKS replicate 2 keratinocyte cell line  Uninfected
GSM2197774 NIKS replicate 3 keratinocyte cell line  Uninfected
GSM2197775 NIKS HPV16-positive replicate 1 keratinocyte cell line  persistent HPV16 Alphapapillomavirus 9
GSM2197776 NIKS HPV16-positive replicate 2 keratinocyte cell line  persistent HPV16 Alphapapillomavirus 9
GSM2197777 NIKS HPV16-positive replicate 3 keratinocyte cell line  persistent HPV16 Alphapapillomavirus 9
GSM2197778 NIKS HPV18-positive replicate 1 keratinocyte cell line  persistent HPV18 Alphapapillomavirus 7
GSM2197779 NIKS HPV18-positive replicate 2 keratinocyte cell line  persistent HPV18 Alphapapillomavirus 7
GSM2197780 NIKS HPV18-positive replicate 3 keratinocyte cell line  persistent HPV18 Alphapapillomavirus 7
GSM2197781 NIKS HPV16-positive E7-deficient replicate 1 keratinocyte cell line  persistent HPV16 Alphapapillomavirus 9 Extra interventions
E7-deficient virus
GSM2197782 NIKS HPV16-positive E7-deficient replicate 2 keratinocyte cell line  persistent HPV16 Alphapapillomavirus 9 Extra interventions
E7-deficient virus
GSM2197783 NIKS HPV16-positive E7-deficient replicate 3 keratinocyte cell line  persistent HPV16 Alphapapillomavirus 9 Extra interventions
E7-deficient virus