Submitted by Terri DiMaio (University of Washington, USA) on Jul 11 2016
Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)
Pubmed: 28257516
Summary Kaposi’s Sarcoma herpesvirus (KSHV), an oncogenic virus, modulates host cell signaling and metabolism to maintain latent infection. To unravel the underlying cellular mechanisms modulated by KSHV, we identified changes in the host proteome, phosphoproteome and transcriptome landscape upon KSHV infection of endothelial cells. A Steiner Forest algorithm was used to integrate proteomic, phosphoproteomic and transcriptomic data with transcriptome based predicted transcription factor activity to identify cellular networks altered by latent KSHV.
ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
---|---|---|---|---|---|---|
GSM2229990 | TIME_Mock_1 | microvascular endothelial cell line [TIME ] | mock | Uninfected | ||
GSM2229991 | TIME_Mock_2 | microvascular endothelial cell line [TIME ] | mock | Uninfected | ||
GSM2229992 | TIME_Mock_3 | microvascular endothelial cell line [TIME ] | mock | Uninfected | ||
GSM2229993 | TIME_KSHV_1 | microvascular endothelial cell line [TIME ] | unknown | KSHV | Human gammaherpesvirus 8 | |
GSM2229994 | TIME_KSHV_2 | microvascular endothelial cell line [TIME ] | unknown | KSHV | Human gammaherpesvirus 8 | |
GSM2229995 | TIME_KSHV_3 | microvascular endothelial cell line [TIME ] | unknown | KSHV | Human gammaherpesvirus 8 |