Virus Expression Database

GSE84237

Integrated Systems Biology Analysis of KSHV Latent Infection Reveals Viral Induction and Reliance on Peroxisome Mediated Lipid Metabolism

Submitted by Terri DiMaio (University of Washington, USA) on Jul 11 2016

Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)

Pubmed: 28257516

Summary Kaposi’s Sarcoma herpesvirus (KSHV), an oncogenic virus, modulates host cell signaling and metabolism to maintain latent infection. To unravel the underlying cellular mechanisms modulated by KSHV, we identified changes in the host proteome, phosphoproteome and transcriptome landscape upon KSHV infection of endothelial cells. A Steiner Forest algorithm was used to integrate proteomic, phosphoproteomic and transcriptomic data with transcriptome based predicted transcription factor activity to identify cellular networks altered by latent KSHV.

6 Samples

ID Title Cell Type Timepoint Reported Virus Virus Species Exclusion Reason
GSM2229990 TIME_Mock_1 microvascular endothelial cell line  [TIME ] mock Uninfected
GSM2229991 TIME_Mock_2 microvascular endothelial cell line  [TIME ] mock Uninfected
GSM2229992 TIME_Mock_3 microvascular endothelial cell line  [TIME ] mock Uninfected
GSM2229993 TIME_KSHV_1 microvascular endothelial cell line  [TIME ] unknown KSHV Human gammaherpesvirus 8
GSM2229994 TIME_KSHV_2 microvascular endothelial cell line  [TIME ] unknown KSHV Human gammaherpesvirus 8
GSM2229995 TIME_KSHV_3 microvascular endothelial cell line  [TIME ] unknown KSHV Human gammaherpesvirus 8