Virus Expression Database
Submitted by Yuqing Li (Sun Yat-sen University, China) on Dec 21 2016
Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)
Pubmed: 29066510
Summary We reported the potential and mechnism of oral mesenchymal stem cell to become Kaposi Sarcoma progenitor cell. Human periodontal ligament cells were infected for 48 hours and 96 hours, then subjected to RNA extraction and sequencing. We found that KSHV-infected PDLSC shared a better similarity with KS biosies in cytokine production, including chemotaxis, angiogenesis, inflammation and differentiation. Furthermore, infection of PDLSC upregulated a spectum of genes involving mesenchymal-to-endothelial differentiation, a process which has been revealed in KS spindle cells. This study reveals the potential and mechnism in which oral mesenchymal stem cell is transformed by KSHV to KS progenitor cell.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM2436210 | Uninfected-1 | periodontal ligament cell  |
uninfected | Uninfected | ||
| GSM2436211 | Uninfected-2 | periodontal ligament cell |
uninfected | Uninfected | ||
| GSM2436212 | Uninfected-3 | periodontal ligament cell |
uninfected | Uninfected | ||
| GSM2436213 | KSHV48-1 | periodontal ligament cell |
48 hrs | KSHV | Human gammaherpesvirus 8 | |
| GSM2436214 | KSHV48-2 | periodontal ligament cell |
48 hrs | KSHV | Human gammaherpesvirus 8 | |
| GSM2436215 | KSHV48-3 | periodontal ligament cell |
48 hrs | KSHV | Human gammaherpesvirus 8 | |
| GSM2436216 | KSHV96-1 | periodontal ligament cell |
96 hrs | KSHV | Human gammaherpesvirus 8 | |
| GSM2436217 | KSHV96-2 | periodontal ligament cell |
96 hrs | KSHV | Human gammaherpesvirus 8 | |
| GSM2436218 | KSHV96-3 | periodontal ligament cell |
96 hrs | KSHV | Human gammaherpesvirus 8 |