Virus Expression Database
Submitted by Daxiang Chen (Southern Medical University, China) on Jan 06 2017
Platform: ngs – Illumina HiSeq 2500 (Homo sapiens)
Pubmed: None listed
Summary Using RNA sequencing technology, we compared specific changes in the transcriptomic profiles in human foreskin fibroblast cells (HFF-1) following ORFV infection. ORFV specifically upregulated and downregulated a variety of genes, including genes involved in antiviral immune response, apoptosis, cell cycle and a series of signaling pathways, such as the IFN and p53-signaling pathways. A range of genes were downregulated at early stage. In contrast, the virus up-regulates a number of cellular genes at late stage.
| ID | Title | Cell Type | Timepoint | Reported Virus | Virus Species | Exclusion Reason |
|---|---|---|---|---|---|---|
| GSM2448850 | 0h_1 | foreskin fibroblast cell line  [HFF-1  ] |
ORFV | Uninfected | ||
| GSM2448851 | 0h_2 | foreskin fibroblast cell line [HFF-1 ] |
ORFV | Uninfected | ||
| GSM2448852 | 0h_3 | foreskin fibroblast cell line [HFF-1 ] |
ORFV | Uninfected | ||
| GSM2448853 | 3h_1 | foreskin fibroblast cell line [HFF-1 ] |
3 hrs | ORFV | Orf virus | |
| GSM2448854 | 3h_2 | foreskin fibroblast cell line [HFF-1 ] |
3 hrs | ORFV | Orf virus | |
| GSM2448855 | 3h_3 | foreskin fibroblast cell line [HFF-1 ] |
3 hrs | ORFV | Orf virus | |
| GSM2448856 | 8h_1 | foreskin fibroblast cell line [HFF-1 ] |
8 hrs | ORFV | Orf virus | |
| GSM2448857 | 8h_2 | foreskin fibroblast cell line [HFF-1 ] |
8 hrs | ORFV | Orf virus | |
| GSM2448858 | 8h_3 | foreskin fibroblast cell line [HFF-1 ] |
8 hrs | ORFV | Orf virus |